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Sleep disordered breathing from preschool to early adult age and its neurocognitive complications: A preliminary report

OBJECTIVE: The onset and development of sleep disordered breathing (SDB) remains unclear in an age - dependent manner. Despite treatment, persistent symptoms such as snoring and excessive daytime sleepiness, as well as cognitive impairment may be present. The aim of the research was to determine the...

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Autores principales: Astara, Kyriaki, Siachpazidou, Dimitra, Vavougios, George D, Ragias, Dimitrios, Vatzia, Konstantina, Rapti, Georgia, Alexopoulos, Emmanouil, Gourgoulianis, Konstantinos I, Xiromerisiou, Georgia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Brazilian Association of Sleep and Latin American Federation of Sleep 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8764947/
https://www.ncbi.nlm.nih.gov/pubmed/35082983
http://dx.doi.org/10.5935/1984-0063.20200098
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author Astara, Kyriaki
Siachpazidou, Dimitra
Vavougios, George D
Ragias, Dimitrios
Vatzia, Konstantina
Rapti, Georgia
Alexopoulos, Emmanouil
Gourgoulianis, Konstantinos I
Xiromerisiou, Georgia
author_facet Astara, Kyriaki
Siachpazidou, Dimitra
Vavougios, George D
Ragias, Dimitrios
Vatzia, Konstantina
Rapti, Georgia
Alexopoulos, Emmanouil
Gourgoulianis, Konstantinos I
Xiromerisiou, Georgia
author_sort Astara, Kyriaki
collection PubMed
description OBJECTIVE: The onset and development of sleep disordered breathing (SDB) remains unclear in an age - dependent manner. Despite treatment, persistent symptoms such as snoring and excessive daytime sleepiness, as well as cognitive impairment may be present. The aim of the research was to determine the prevalence of residual symptoms of SDB in adolescence and early adulthood, the predisposing factors and its neurocognitive complications. METHODS: In the present pilot study-cohort, a questionnaire was utilized to 154 people (average age: 17.9 ± 3), who as children (mean age: 5.3 ± 1.4) had AHI ≥2.5 episodes/h. They were divided into two groups based on AHI = 5 episodes/h. Depending on the results, they were invited to undergo a repeated polysomnography (PSG) and complete the Montreal Cognitive Assessment (MoCA) test. Statistical analysis was made with IBM SPSS software. RESULTS: Out of the total, 35.7% claimed to still snore. AHI was negatively correlated to the severity of residual symptoms (Mann-Witney U test, p <0.005). According to repeated PSGs, 9/17 met the criteria for OSAS, while high BMI was associated with the severity of new AHI (chi squared test, p<0.005). Additionally, 7/16 scored below the MoCA baseline (<26/30). The characteristics of cognitive declines were mapped, with most prominent having been visuospatial, short - term memory and naming/language deficits. DISCUSSION: A significant percentage of children with sleep breathing disorder present with residual symptoms during their transition to early adulthood, as well as undiagnosed neurocognitive complications. Clinicians suspicion for the underlying neurocognitive complications is required, even in young adults, while guidelines on monitoring pediatric OSAS patients after treatment should be addressed.
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spelling pubmed-87649472022-01-25 Sleep disordered breathing from preschool to early adult age and its neurocognitive complications: A preliminary report Astara, Kyriaki Siachpazidou, Dimitra Vavougios, George D Ragias, Dimitrios Vatzia, Konstantina Rapti, Georgia Alexopoulos, Emmanouil Gourgoulianis, Konstantinos I Xiromerisiou, Georgia Sleep Sci Original Article OBJECTIVE: The onset and development of sleep disordered breathing (SDB) remains unclear in an age - dependent manner. Despite treatment, persistent symptoms such as snoring and excessive daytime sleepiness, as well as cognitive impairment may be present. The aim of the research was to determine the prevalence of residual symptoms of SDB in adolescence and early adulthood, the predisposing factors and its neurocognitive complications. METHODS: In the present pilot study-cohort, a questionnaire was utilized to 154 people (average age: 17.9 ± 3), who as children (mean age: 5.3 ± 1.4) had AHI ≥2.5 episodes/h. They were divided into two groups based on AHI = 5 episodes/h. Depending on the results, they were invited to undergo a repeated polysomnography (PSG) and complete the Montreal Cognitive Assessment (MoCA) test. Statistical analysis was made with IBM SPSS software. RESULTS: Out of the total, 35.7% claimed to still snore. AHI was negatively correlated to the severity of residual symptoms (Mann-Witney U test, p <0.005). According to repeated PSGs, 9/17 met the criteria for OSAS, while high BMI was associated with the severity of new AHI (chi squared test, p<0.005). Additionally, 7/16 scored below the MoCA baseline (<26/30). The characteristics of cognitive declines were mapped, with most prominent having been visuospatial, short - term memory and naming/language deficits. DISCUSSION: A significant percentage of children with sleep breathing disorder present with residual symptoms during their transition to early adulthood, as well as undiagnosed neurocognitive complications. Clinicians suspicion for the underlying neurocognitive complications is required, even in young adults, while guidelines on monitoring pediatric OSAS patients after treatment should be addressed. Brazilian Association of Sleep and Latin American Federation of Sleep 2021 /pmc/articles/PMC8764947/ /pubmed/35082983 http://dx.doi.org/10.5935/1984-0063.20200098 Text en https://creativecommons.org/licenses/by/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Astara, Kyriaki
Siachpazidou, Dimitra
Vavougios, George D
Ragias, Dimitrios
Vatzia, Konstantina
Rapti, Georgia
Alexopoulos, Emmanouil
Gourgoulianis, Konstantinos I
Xiromerisiou, Georgia
Sleep disordered breathing from preschool to early adult age and its neurocognitive complications: A preliminary report
title Sleep disordered breathing from preschool to early adult age and its neurocognitive complications: A preliminary report
title_full Sleep disordered breathing from preschool to early adult age and its neurocognitive complications: A preliminary report
title_fullStr Sleep disordered breathing from preschool to early adult age and its neurocognitive complications: A preliminary report
title_full_unstemmed Sleep disordered breathing from preschool to early adult age and its neurocognitive complications: A preliminary report
title_short Sleep disordered breathing from preschool to early adult age and its neurocognitive complications: A preliminary report
title_sort sleep disordered breathing from preschool to early adult age and its neurocognitive complications: a preliminary report
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8764947/
https://www.ncbi.nlm.nih.gov/pubmed/35082983
http://dx.doi.org/10.5935/1984-0063.20200098
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