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Endometriosis and gynaecological cancers: molecular insights behind a complex machinery
Endometriosis is described as the presence of both endometrial glandular and stromal cells outside the uterine cavity. A major characterization of this disease is ectopic implantation of endometrial cells with increased migration. It is one of the leading causes of morbidity among premenopausal wome...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Termedia Publishing House
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8764963/ https://www.ncbi.nlm.nih.gov/pubmed/35069072 http://dx.doi.org/10.5114/pm.2021.111276 |
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author | Vetvicka, Vaclav Fiala, Ludek Garzon, Simone Buzzaccarini, Giovanni Terzic, Milan Laganà, Antonio Simone |
author_facet | Vetvicka, Vaclav Fiala, Ludek Garzon, Simone Buzzaccarini, Giovanni Terzic, Milan Laganà, Antonio Simone |
author_sort | Vetvicka, Vaclav |
collection | PubMed |
description | Endometriosis is described as the presence of both endometrial glandular and stromal cells outside the uterine cavity. A major characterization of this disease is ectopic implantation of endometrial cells with increased migration. It is one of the leading causes of morbidity among premenopausal women, with a prevalence of 10–16% of women of reproductive age. Despite over century of intensive research, none of the current treatment options represents a real cure. Based on the current knowledge, endometriosis, particularly its atypical version, is considered to be a transitional form from benign disease to tumour. However, the exact mechanisms of this conversion are still not fully established. |
format | Online Article Text |
id | pubmed-8764963 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Termedia Publishing House |
record_format | MEDLINE/PubMed |
spelling | pubmed-87649632022-01-21 Endometriosis and gynaecological cancers: molecular insights behind a complex machinery Vetvicka, Vaclav Fiala, Ludek Garzon, Simone Buzzaccarini, Giovanni Terzic, Milan Laganà, Antonio Simone Prz Menopauzalny Review Paper Endometriosis is described as the presence of both endometrial glandular and stromal cells outside the uterine cavity. A major characterization of this disease is ectopic implantation of endometrial cells with increased migration. It is one of the leading causes of morbidity among premenopausal women, with a prevalence of 10–16% of women of reproductive age. Despite over century of intensive research, none of the current treatment options represents a real cure. Based on the current knowledge, endometriosis, particularly its atypical version, is considered to be a transitional form from benign disease to tumour. However, the exact mechanisms of this conversion are still not fully established. Termedia Publishing House 2021-12-06 2021-12 /pmc/articles/PMC8764963/ /pubmed/35069072 http://dx.doi.org/10.5114/pm.2021.111276 Text en Copyright © 2021 Termedia https://creativecommons.org/licenses/by-nc-sa/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0). License (http://creativecommons.org/licenses/by-nc-sa/4.0/ (https://creativecommons.org/licenses/by-nc-sa/4.0/) ) |
spellingShingle | Review Paper Vetvicka, Vaclav Fiala, Ludek Garzon, Simone Buzzaccarini, Giovanni Terzic, Milan Laganà, Antonio Simone Endometriosis and gynaecological cancers: molecular insights behind a complex machinery |
title | Endometriosis and gynaecological cancers: molecular insights behind a complex machinery |
title_full | Endometriosis and gynaecological cancers: molecular insights behind a complex machinery |
title_fullStr | Endometriosis and gynaecological cancers: molecular insights behind a complex machinery |
title_full_unstemmed | Endometriosis and gynaecological cancers: molecular insights behind a complex machinery |
title_short | Endometriosis and gynaecological cancers: molecular insights behind a complex machinery |
title_sort | endometriosis and gynaecological cancers: molecular insights behind a complex machinery |
topic | Review Paper |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8764963/ https://www.ncbi.nlm.nih.gov/pubmed/35069072 http://dx.doi.org/10.5114/pm.2021.111276 |
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