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Endometriosis and gynaecological cancers: molecular insights behind a complex machinery

Endometriosis is described as the presence of both endometrial glandular and stromal cells outside the uterine cavity. A major characterization of this disease is ectopic implantation of endometrial cells with increased migration. It is one of the leading causes of morbidity among premenopausal wome...

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Autores principales: Vetvicka, Vaclav, Fiala, Ludek, Garzon, Simone, Buzzaccarini, Giovanni, Terzic, Milan, Laganà, Antonio Simone
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Termedia Publishing House 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8764963/
https://www.ncbi.nlm.nih.gov/pubmed/35069072
http://dx.doi.org/10.5114/pm.2021.111276
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author Vetvicka, Vaclav
Fiala, Ludek
Garzon, Simone
Buzzaccarini, Giovanni
Terzic, Milan
Laganà, Antonio Simone
author_facet Vetvicka, Vaclav
Fiala, Ludek
Garzon, Simone
Buzzaccarini, Giovanni
Terzic, Milan
Laganà, Antonio Simone
author_sort Vetvicka, Vaclav
collection PubMed
description Endometriosis is described as the presence of both endometrial glandular and stromal cells outside the uterine cavity. A major characterization of this disease is ectopic implantation of endometrial cells with increased migration. It is one of the leading causes of morbidity among premenopausal women, with a prevalence of 10–16% of women of reproductive age. Despite over century of intensive research, none of the current treatment options represents a real cure. Based on the current knowledge, endometriosis, particularly its atypical version, is considered to be a transitional form from benign disease to tumour. However, the exact mechanisms of this conversion are still not fully established.
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spelling pubmed-87649632022-01-21 Endometriosis and gynaecological cancers: molecular insights behind a complex machinery Vetvicka, Vaclav Fiala, Ludek Garzon, Simone Buzzaccarini, Giovanni Terzic, Milan Laganà, Antonio Simone Prz Menopauzalny Review Paper Endometriosis is described as the presence of both endometrial glandular and stromal cells outside the uterine cavity. A major characterization of this disease is ectopic implantation of endometrial cells with increased migration. It is one of the leading causes of morbidity among premenopausal women, with a prevalence of 10–16% of women of reproductive age. Despite over century of intensive research, none of the current treatment options represents a real cure. Based on the current knowledge, endometriosis, particularly its atypical version, is considered to be a transitional form from benign disease to tumour. However, the exact mechanisms of this conversion are still not fully established. Termedia Publishing House 2021-12-06 2021-12 /pmc/articles/PMC8764963/ /pubmed/35069072 http://dx.doi.org/10.5114/pm.2021.111276 Text en Copyright © 2021 Termedia https://creativecommons.org/licenses/by-nc-sa/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0). License (http://creativecommons.org/licenses/by-nc-sa/4.0/ (https://creativecommons.org/licenses/by-nc-sa/4.0/) )
spellingShingle Review Paper
Vetvicka, Vaclav
Fiala, Ludek
Garzon, Simone
Buzzaccarini, Giovanni
Terzic, Milan
Laganà, Antonio Simone
Endometriosis and gynaecological cancers: molecular insights behind a complex machinery
title Endometriosis and gynaecological cancers: molecular insights behind a complex machinery
title_full Endometriosis and gynaecological cancers: molecular insights behind a complex machinery
title_fullStr Endometriosis and gynaecological cancers: molecular insights behind a complex machinery
title_full_unstemmed Endometriosis and gynaecological cancers: molecular insights behind a complex machinery
title_short Endometriosis and gynaecological cancers: molecular insights behind a complex machinery
title_sort endometriosis and gynaecological cancers: molecular insights behind a complex machinery
topic Review Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8764963/
https://www.ncbi.nlm.nih.gov/pubmed/35069072
http://dx.doi.org/10.5114/pm.2021.111276
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