Cell stress response impairs de novo NAD(+) biosynthesis in the kidney

The biosynthetic routes leading to de novo nicotinamide adenine dinucleotide (NAD(+)) production are involved in acute kidney injury (AKI), with a critical role for quinolinate phosphoribosyl transferase (QPRT), a bottleneck enzyme of de novo NAD(+) biosynthesis. The molecular mechanisms determining...

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Detalles Bibliográficos
Autores principales: Bignon, Yohan, Rinaldi, Anna, Nadour, Zahia, Poindessous, Virginie, Nemazanyy, Ivan, Lenoir, Olivia, Fohlen, Baptiste, Weill-Raynal, Pierre, Hertig, Alexandre, Karras, Alexandre, Galichon, Pierre, Naesens, Maarten, Anglicheau, Dany, Cippà, Pietro E., Pallet, Nicolas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Clinical Investigation 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8765040/
https://www.ncbi.nlm.nih.gov/pubmed/34793337
http://dx.doi.org/10.1172/jci.insight.153019

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