Intravital imaging reveals glomerular capillary distension and endothelial and immune cell activation early in Alport syndrome

Alport syndrome (AS) is a genetic disorder caused by mutations in type IV collagen that lead to defective glomerular basement membrane, glomerular filtration barrier (GFB) damage, and progressive chronic kidney disease. While the genetic basis of AS is well known, the molecular and cellular mechanis...

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Detalles Bibliográficos
Autores principales: Gyarmati, Georgina, Shroff, Urvi Nikhil, Izuhara, Audrey, Hou, Xiaogang, Da Sacco, Stefano, Sedrakyan, Sargis, Lemley, Kevin V., Amann, Kerstin, Perin, Laura, Peti-Peterdi, János
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Clinical Investigation 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8765042/
https://www.ncbi.nlm.nih.gov/pubmed/34793332
http://dx.doi.org/10.1172/jci.insight.152676

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