Extracellular vesicles: a promising cell-free therapy for cartilage repair

Few effective therapies for cartilage repair have been found as cartilage has a low regenerative capacity. Extracellular vesicles (EVs), including exosomes, are produced by cells and contain bioactive components such as nucleic acids, proteins, lipids and other metabolites that have potential for tr...

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Detalles Bibliográficos
Autores principales: Amsar, Rizka Musdalifah, Wijaya, Christofora Hanny, Ana, Ika Dewi, Hidajah, Atik Choirul, Notobroto, Hari Basuki, Kencana Wungu, Triati Dewi, Barlian, Anggraini
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Future Science Ltd 2021
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8765097/
https://www.ncbi.nlm.nih.gov/pubmed/35070356
http://dx.doi.org/10.2144/fsoa-2021-0096
Descripción
Sumario:Few effective therapies for cartilage repair have been found as cartilage has a low regenerative capacity. Extracellular vesicles (EVs), including exosomes, are produced by cells and contain bioactive components such as nucleic acids, proteins, lipids and other metabolites that have potential for treating cartilage injuries. Challenges like the difficulty in standardizing targeted therapy have prevented EVs from being used frequently as a treatment option. In this review we present current studies, mechanisms and delivery strategies of EVs. Additionally, we describe the challenges and future directions of EVs as therapeutic agents for cartilage repair.

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