Extracellular vesicles: a promising cell-free therapy for cartilage repair

Few effective therapies for cartilage repair have been found as cartilage has a low regenerative capacity. Extracellular vesicles (EVs), including exosomes, are produced by cells and contain bioactive components such as nucleic acids, proteins, lipids and other metabolites that have potential for tr...

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Autores principales: Amsar, Rizka Musdalifah, Wijaya, Christofora Hanny, Ana, Ika Dewi, Hidajah, Atik Choirul, Notobroto, Hari Basuki, Kencana Wungu, Triati Dewi, Barlian, Anggraini
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Future Science Ltd 2021
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8765097/
https://www.ncbi.nlm.nih.gov/pubmed/35070356
http://dx.doi.org/10.2144/fsoa-2021-0096
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author Amsar, Rizka Musdalifah
Wijaya, Christofora Hanny
Ana, Ika Dewi
Hidajah, Atik Choirul
Notobroto, Hari Basuki
Kencana Wungu, Triati Dewi
Barlian, Anggraini
author_facet Amsar, Rizka Musdalifah
Wijaya, Christofora Hanny
Ana, Ika Dewi
Hidajah, Atik Choirul
Notobroto, Hari Basuki
Kencana Wungu, Triati Dewi
Barlian, Anggraini
author_sort Amsar, Rizka Musdalifah
collection PubMed
description Few effective therapies for cartilage repair have been found as cartilage has a low regenerative capacity. Extracellular vesicles (EVs), including exosomes, are produced by cells and contain bioactive components such as nucleic acids, proteins, lipids and other metabolites that have potential for treating cartilage injuries. Challenges like the difficulty in standardizing targeted therapy have prevented EVs from being used frequently as a treatment option. In this review we present current studies, mechanisms and delivery strategies of EVs. Additionally, we describe the challenges and future directions of EVs as therapeutic agents for cartilage repair.
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spelling pubmed-87650972022-01-20 Extracellular vesicles: a promising cell-free therapy for cartilage repair Amsar, Rizka Musdalifah Wijaya, Christofora Hanny Ana, Ika Dewi Hidajah, Atik Choirul Notobroto, Hari Basuki Kencana Wungu, Triati Dewi Barlian, Anggraini Future Sci OA Review Few effective therapies for cartilage repair have been found as cartilage has a low regenerative capacity. Extracellular vesicles (EVs), including exosomes, are produced by cells and contain bioactive components such as nucleic acids, proteins, lipids and other metabolites that have potential for treating cartilage injuries. Challenges like the difficulty in standardizing targeted therapy have prevented EVs from being used frequently as a treatment option. In this review we present current studies, mechanisms and delivery strategies of EVs. Additionally, we describe the challenges and future directions of EVs as therapeutic agents for cartilage repair. Future Science Ltd 2021-12-06 /pmc/articles/PMC8765097/ /pubmed/35070356 http://dx.doi.org/10.2144/fsoa-2021-0096 Text en © 2021 Anggraini Barlian https://creativecommons.org/licenses/by/4.0/This work is licensed under the Creative Commons Attribution 4.0 License (https://creativecommons.org/licenses/by/4.0/)
spellingShingle Review
Amsar, Rizka Musdalifah
Wijaya, Christofora Hanny
Ana, Ika Dewi
Hidajah, Atik Choirul
Notobroto, Hari Basuki
Kencana Wungu, Triati Dewi
Barlian, Anggraini
Extracellular vesicles: a promising cell-free therapy for cartilage repair
title Extracellular vesicles: a promising cell-free therapy for cartilage repair
title_full Extracellular vesicles: a promising cell-free therapy for cartilage repair
title_fullStr Extracellular vesicles: a promising cell-free therapy for cartilage repair
title_full_unstemmed Extracellular vesicles: a promising cell-free therapy for cartilage repair
title_short Extracellular vesicles: a promising cell-free therapy for cartilage repair
title_sort extracellular vesicles: a promising cell-free therapy for cartilage repair
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8765097/
https://www.ncbi.nlm.nih.gov/pubmed/35070356
http://dx.doi.org/10.2144/fsoa-2021-0096
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