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Decreased Methylenetetrahydrofolate Reductase Activity Leads to Increased Sensitivity to para-Aminosalicylic Acid in Mycobacterium tuberculosis

Tuberculosis (TB), caused by Mycobacterium tuberculosis, is one of the most fatal diseases in the world. Methylenetetrahydrofolate reductase (MTHFR) catalyzes the production of 5-methyltetrahydrofolate (5-CH(3)-THF), which is required for the de novo biosynthesis of methionine in bacteria. Here, we...

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Detalles Bibliográficos
Autores principales:	Yu, Ji-fang, Xu, Jin-tian, Yang, Shan-shan, Gao, Mei-na, Si, Hao-rui, Xiong, Dong-yan, Gu, Jing, Wu, Zhi-long, Zhou, Jie, Deng, Jiao-yu
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Microbiology 2022
Materias:	Mechanisms of Resistance
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8765232/ https://www.ncbi.nlm.nih.gov/pubmed/34780266 http://dx.doi.org/10.1128/AAC.01465-21

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