Antifungal-Loaded Calcium Sulfate Beads as a Potential Therapeutic in Combating Candida auris

Candida auris provides a substantial global nosocomial threat clinically. With the recent emergence that the organism can readily colonize skin niches, it will likely continue to pose a risk in health care units, particularly to patients undergoing surgery. The purpose of this study was to investiga...

Descripción completa

Detalles Bibliográficos
Autores principales: Butcher, Mark C., Brown, Jason L., Hansom, Donald, Wilson-Van Os, Rebecca, Delury, Craig, Laycock, Phillip A., Ramage, Gordon
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Microbiology 2022
Materias:
Clinical Therapeutics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8765289/
https://www.ncbi.nlm.nih.gov/pubmed/34694875
http://dx.doi.org/10.1128/AAC.01713-21
_version_ 1784634309319065600
author Butcher, Mark C.
Brown, Jason L.
Hansom, Donald
Wilson-Van Os, Rebecca
Delury, Craig
Laycock, Phillip A.
Ramage, Gordon
author_facet Butcher, Mark C.
Brown, Jason L.
Hansom, Donald
Wilson-Van Os, Rebecca
Delury, Craig
Laycock, Phillip A.
Ramage, Gordon
author_sort Butcher, Mark C.
collection PubMed
description Candida auris provides a substantial global nosocomial threat clinically. With the recent emergence that the organism can readily colonize skin niches, it will likely continue to pose a risk in health care units, particularly to patients undergoing surgery. The purpose of this study was to investigate the efficacy of antifungal-loaded calcium sulfate (CS) beads in combatting C. auris infection. We demonstrate that the CS-packed beads have the potential to interfere with planktonic and sessile C. auris.
format Online
Article
Text
id pubmed-8765289
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher American Society for Microbiology
record_format MEDLINE/PubMed
spelling pubmed-87652892022-01-24 Antifungal-Loaded Calcium Sulfate Beads as a Potential Therapeutic in Combating Candida auris Butcher, Mark C. Brown, Jason L. Hansom, Donald Wilson-Van Os, Rebecca Delury, Craig Laycock, Phillip A. Ramage, Gordon Antimicrob Agents Chemother Clinical Therapeutics Candida auris provides a substantial global nosocomial threat clinically. With the recent emergence that the organism can readily colonize skin niches, it will likely continue to pose a risk in health care units, particularly to patients undergoing surgery. The purpose of this study was to investigate the efficacy of antifungal-loaded calcium sulfate (CS) beads in combatting C. auris infection. We demonstrate that the CS-packed beads have the potential to interfere with planktonic and sessile C. auris. American Society for Microbiology 2022-01-18 /pmc/articles/PMC8765289/ /pubmed/34694875 http://dx.doi.org/10.1128/AAC.01713-21 Text en Copyright © 2022 Butcher et al. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Clinical Therapeutics
Butcher, Mark C.
Brown, Jason L.
Hansom, Donald
Wilson-Van Os, Rebecca
Delury, Craig
Laycock, Phillip A.
Ramage, Gordon
Antifungal-Loaded Calcium Sulfate Beads as a Potential Therapeutic in Combating Candida auris
title Antifungal-Loaded Calcium Sulfate Beads as a Potential Therapeutic in Combating Candida auris
title_full Antifungal-Loaded Calcium Sulfate Beads as a Potential Therapeutic in Combating Candida auris
title_fullStr Antifungal-Loaded Calcium Sulfate Beads as a Potential Therapeutic in Combating Candida auris
title_full_unstemmed Antifungal-Loaded Calcium Sulfate Beads as a Potential Therapeutic in Combating Candida auris
title_short Antifungal-Loaded Calcium Sulfate Beads as a Potential Therapeutic in Combating Candida auris
title_sort antifungal-loaded calcium sulfate beads as a potential therapeutic in combating candida auris
topic Clinical Therapeutics
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8765289/
https://www.ncbi.nlm.nih.gov/pubmed/34694875
http://dx.doi.org/10.1128/AAC.01713-21
work_keys_str_mv AT butchermarkc antifungalloadedcalciumsulfatebeadsasapotentialtherapeuticincombatingcandidaauris
AT brownjasonl antifungalloadedcalciumsulfatebeadsasapotentialtherapeuticincombatingcandidaauris
AT hansomdonald antifungalloadedcalciumsulfatebeadsasapotentialtherapeuticincombatingcandidaauris
AT wilsonvanosrebecca antifungalloadedcalciumsulfatebeadsasapotentialtherapeuticincombatingcandidaauris
AT delurycraig antifungalloadedcalciumsulfatebeadsasapotentialtherapeuticincombatingcandidaauris
AT laycockphillipa antifungalloadedcalciumsulfatebeadsasapotentialtherapeuticincombatingcandidaauris
AT ramagegordon antifungalloadedcalciumsulfatebeadsasapotentialtherapeuticincombatingcandidaauris

Ejemplares similares