Inhibitor-Resistant Mutants Give Important Insights into Candida albicans ABC Transporter Cdr1 Substrate Specificity and Help Elucidate Efflux Pump Inhibition

Overexpression of ATP-binding cassette (ABC) transporters is a major cause of drug resistance in fungal pathogens. Milbemycins, enniatin B, beauvericin, and FK506 are promising leads for broad-spectrum fungal multidrug efflux pump inhibitors. The characterization of naturally generated inhibitor-res...

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Detalles Bibliográficos
Autores principales: Niimi, Masakazu, Niimi, Kyoko, Tanabe, Koichi, Cannon, Richard D., Lamping, Erwin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Microbiology 2022
Materias:
Mechanisms of Resistance
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8765293/
https://www.ncbi.nlm.nih.gov/pubmed/34780272
http://dx.doi.org/10.1128/AAC.01748-21

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8765293/
https://www.ncbi.nlm.nih.gov/pubmed/34780272
http://dx.doi.org/10.1128/AAC.01748-21

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