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Identification of a Proteasome-Targeting Arylsulfonamide with Potential for the Treatment of Chagas’ Disease

Phenotypic screening identified an arylsulfonamide compound with activity against Trypanosoma cruzi, the causative agent of Chagas’ disease. Comprehensive mode of action studies revealed that this compound primarily targets the T. cruzi proteasome, binding at the interface between β4 and β5 subunits...

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Detalles Bibliográficos
Autores principales:	Lima, Marta L., Tulloch, Lindsay B., Corpas-Lopez, Victoriano, Carvalho, Sandra, Wall, Richard J., Milne, Rachel, Rico, Eva, Patterson, Stephen, Gilbert, Ian H., Moniz, Sonia, MacLean, Lorna, Torrie, Leah S., Morgillo, Carmine, Horn, David, Zuccotto, Fabio, Wyllie, Susan
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Microbiology 2022
Materias:	Mechanisms of Action: Physiological Effects
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8765320/ https://www.ncbi.nlm.nih.gov/pubmed/34606338 http://dx.doi.org/10.1128/AAC.01535-21

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