Exposing cryptic epitopes on the Venezuelan equine encephalitis virus E1 glycoprotein prior to treatment with alphavirus cross-reactive monoclonal antibody allows blockage of replication early in infection

Eastern equine encephalitis virus (EEEV), western equine encephalitis virus (WEEV) and Venezuelan equine encephalitis virus (VEEV) can cause fatal encephalitis in humans and equids. Some MAbs to the E1 glycoprotein are known to be cross-reactive, weakly neutralizing in vitro but can protect from dis...

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Detalles Bibliográficos
Autores principales: Calvert, Amanda E., Bennett, Susan L., Hunt, Ann R., Fong, Rachel H., Doranz, Benjamin J., Roehrig, John T., Blair, Carol D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8765347/
https://www.ncbi.nlm.nih.gov/pubmed/34626907
http://dx.doi.org/10.1016/j.virol.2021.09.007

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