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Chimeric chromosome landscapes of human somatic cell cultures show dependence on stress and regulation of genomic repeats by CGGBP1

Genomes of somatic cells in culture are prone to spontaneous mutations due to errors in replication and DNA repair. Some of these errors, such as chromosomal fusions, are not rectifiable and subject to selection or elimination in growing cultures. Somatic cell cultures are thus expected to generate...

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Detalles Bibliográficos
Autores principales: Datta, Subhamoy, Patel, Manthan, Kashyap, Sukesh, Patel, Divyesh, Singh, Umashankar
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8765472/
https://www.ncbi.nlm.nih.gov/pubmed/35070079
http://dx.doi.org/10.18632/oncotarget.28174