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Association of Serum Complement C1q and C3 Level with Age-Related Macular Degeneration in Women

PURPOSE: To investigate the association between serum complement components and age-related macular degeneration (AMD). PATIENTS AND METHODS: A total of 118 AMD patients and age- and sex-matched 106 control subjects were included. Demographic data and the level of serum complement component (C)1q, C...

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Autores principales: Ma, Yingbo, Ding, Xueqing, Shao, Mingxi, Qiu, Yichao, Li, Shengjie, Cao, Wenjun, Xu, Gezhi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8765539/
https://www.ncbi.nlm.nih.gov/pubmed/35058703
http://dx.doi.org/10.2147/JIR.S348539
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author Ma, Yingbo
Ding, Xueqing
Shao, Mingxi
Qiu, Yichao
Li, Shengjie
Cao, Wenjun
Xu, Gezhi
author_facet Ma, Yingbo
Ding, Xueqing
Shao, Mingxi
Qiu, Yichao
Li, Shengjie
Cao, Wenjun
Xu, Gezhi
author_sort Ma, Yingbo
collection PubMed
description PURPOSE: To investigate the association between serum complement components and age-related macular degeneration (AMD). PATIENTS AND METHODS: A total of 118 AMD patients and age- and sex-matched 106 control subjects were included. Demographic data and the level of serum complement component (C)1q, C3 and C4 were evaluated. Based on sex, the subjects were stratified into male and female subgroups. RESULTS: The level of C1q (226.31±45.33mg/dL) was significantly higher and C3 (121.14±15.76mg/dL) was significantly lower than that in control group (200.03±38.54mg/dL) (128.42±19.81mg/dL) in the female AMD patients (p = 0.005, p = 0.045). Logistic regression showed that increased C1q (OR = 1.132, p = 0.016) and decreased C3 (OR = 0.960, p = 0.048) were independent risk factors for female AMD patients. No statistical significance was observed in the male. CONCLUSION: Increased C1q and decreased C3 were associated with increased risk of AMD, suggesting that the complement classical pathway probably be involved in AMD, especially in female.
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spelling pubmed-87655392022-01-19 Association of Serum Complement C1q and C3 Level with Age-Related Macular Degeneration in Women Ma, Yingbo Ding, Xueqing Shao, Mingxi Qiu, Yichao Li, Shengjie Cao, Wenjun Xu, Gezhi J Inflamm Res Original Research PURPOSE: To investigate the association between serum complement components and age-related macular degeneration (AMD). PATIENTS AND METHODS: A total of 118 AMD patients and age- and sex-matched 106 control subjects were included. Demographic data and the level of serum complement component (C)1q, C3 and C4 were evaluated. Based on sex, the subjects were stratified into male and female subgroups. RESULTS: The level of C1q (226.31±45.33mg/dL) was significantly higher and C3 (121.14±15.76mg/dL) was significantly lower than that in control group (200.03±38.54mg/dL) (128.42±19.81mg/dL) in the female AMD patients (p = 0.005, p = 0.045). Logistic regression showed that increased C1q (OR = 1.132, p = 0.016) and decreased C3 (OR = 0.960, p = 0.048) were independent risk factors for female AMD patients. No statistical significance was observed in the male. CONCLUSION: Increased C1q and decreased C3 were associated with increased risk of AMD, suggesting that the complement classical pathway probably be involved in AMD, especially in female. Dove 2022-01-14 /pmc/articles/PMC8765539/ /pubmed/35058703 http://dx.doi.org/10.2147/JIR.S348539 Text en © 2022 Ma et al. https://creativecommons.org/licenses/by-nc/3.0/This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/ (https://creativecommons.org/licenses/by-nc/3.0/) ). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms (https://www.dovepress.com/terms.php).
spellingShingle Original Research
Ma, Yingbo
Ding, Xueqing
Shao, Mingxi
Qiu, Yichao
Li, Shengjie
Cao, Wenjun
Xu, Gezhi
Association of Serum Complement C1q and C3 Level with Age-Related Macular Degeneration in Women
title Association of Serum Complement C1q and C3 Level with Age-Related Macular Degeneration in Women
title_full Association of Serum Complement C1q and C3 Level with Age-Related Macular Degeneration in Women
title_fullStr Association of Serum Complement C1q and C3 Level with Age-Related Macular Degeneration in Women
title_full_unstemmed Association of Serum Complement C1q and C3 Level with Age-Related Macular Degeneration in Women
title_short Association of Serum Complement C1q and C3 Level with Age-Related Macular Degeneration in Women
title_sort association of serum complement c1q and c3 level with age-related macular degeneration in women
topic Original Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8765539/
https://www.ncbi.nlm.nih.gov/pubmed/35058703
http://dx.doi.org/10.2147/JIR.S348539
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