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Cost-effective synthesis of 2D molybdenum disulfide (MoS(2)) nanocrystals: An exploration of the influence on cellular uptake, cytotoxicity, and bio-imaging

Ultrasmall MoS(2) nanocrystals have unique optoelectronic and catalytic properties that have acquired significant attraction in many areas. We propose here a simple and economical method for synthesizing the luminescent nanocrystals MoS(2) using the hydrothermal technique. In addition, the synthesiz...

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Autores principales: Sahoo, Dhirendra, Behera, Sushreesangita P., Shakya, Jyoti, Kaviraj, Bhaskar
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8765608/
https://www.ncbi.nlm.nih.gov/pubmed/35041665
http://dx.doi.org/10.1371/journal.pone.0260955
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author Sahoo, Dhirendra
Behera, Sushreesangita P.
Shakya, Jyoti
Kaviraj, Bhaskar
author_facet Sahoo, Dhirendra
Behera, Sushreesangita P.
Shakya, Jyoti
Kaviraj, Bhaskar
author_sort Sahoo, Dhirendra
collection PubMed
description Ultrasmall MoS(2) nanocrystals have unique optoelectronic and catalytic properties that have acquired significant attraction in many areas. We propose here a simple and economical method for synthesizing the luminescent nanocrystals MoS(2) using the hydrothermal technique. In addition, the synthesized MoS(2) nanocrystals display photoluminescence that is tunable according to size. MoS(2) nanocrystals have many advantages, such as stable dispersion, low toxicity and luminescent characteristics, offering their encouraging applicability in biomedical disciplines. In this study, human lung cancer epithelial cells (A549) are used to assess fluorescence imaging of MoS(2) nanocrystals. MTT assay, trypan blue assay, flow cytometry and fluorescence imaging results have shown that MoS(2) nanocrystals can selectively target and destroy lung cancer cells, especially drug-resistant cells (A549).
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spelling pubmed-87656082022-01-19 Cost-effective synthesis of 2D molybdenum disulfide (MoS(2)) nanocrystals: An exploration of the influence on cellular uptake, cytotoxicity, and bio-imaging Sahoo, Dhirendra Behera, Sushreesangita P. Shakya, Jyoti Kaviraj, Bhaskar PLoS One Research Article Ultrasmall MoS(2) nanocrystals have unique optoelectronic and catalytic properties that have acquired significant attraction in many areas. We propose here a simple and economical method for synthesizing the luminescent nanocrystals MoS(2) using the hydrothermal technique. In addition, the synthesized MoS(2) nanocrystals display photoluminescence that is tunable according to size. MoS(2) nanocrystals have many advantages, such as stable dispersion, low toxicity and luminescent characteristics, offering their encouraging applicability in biomedical disciplines. In this study, human lung cancer epithelial cells (A549) are used to assess fluorescence imaging of MoS(2) nanocrystals. MTT assay, trypan blue assay, flow cytometry and fluorescence imaging results have shown that MoS(2) nanocrystals can selectively target and destroy lung cancer cells, especially drug-resistant cells (A549). Public Library of Science 2022-01-18 /pmc/articles/PMC8765608/ /pubmed/35041665 http://dx.doi.org/10.1371/journal.pone.0260955 Text en © 2022 Sahoo et al https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Article
Sahoo, Dhirendra
Behera, Sushreesangita P.
Shakya, Jyoti
Kaviraj, Bhaskar
Cost-effective synthesis of 2D molybdenum disulfide (MoS(2)) nanocrystals: An exploration of the influence on cellular uptake, cytotoxicity, and bio-imaging
title Cost-effective synthesis of 2D molybdenum disulfide (MoS(2)) nanocrystals: An exploration of the influence on cellular uptake, cytotoxicity, and bio-imaging
title_full Cost-effective synthesis of 2D molybdenum disulfide (MoS(2)) nanocrystals: An exploration of the influence on cellular uptake, cytotoxicity, and bio-imaging
title_fullStr Cost-effective synthesis of 2D molybdenum disulfide (MoS(2)) nanocrystals: An exploration of the influence on cellular uptake, cytotoxicity, and bio-imaging
title_full_unstemmed Cost-effective synthesis of 2D molybdenum disulfide (MoS(2)) nanocrystals: An exploration of the influence on cellular uptake, cytotoxicity, and bio-imaging
title_short Cost-effective synthesis of 2D molybdenum disulfide (MoS(2)) nanocrystals: An exploration of the influence on cellular uptake, cytotoxicity, and bio-imaging
title_sort cost-effective synthesis of 2d molybdenum disulfide (mos(2)) nanocrystals: an exploration of the influence on cellular uptake, cytotoxicity, and bio-imaging
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8765608/
https://www.ncbi.nlm.nih.gov/pubmed/35041665
http://dx.doi.org/10.1371/journal.pone.0260955
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