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Effect of prorenin peptide vaccine on the early phase of diabetic retinopathy in a murine model of type 2 diabetes

Prorenin is viewed as an ideal target molecule in the prevention of diabetic retinopathy. However, no drugs are available for inhibiting activation of prorenin. Here, we tested the effect of a prorenin peptide vaccine (V(P)) in the retina of a murine model of type 2 diabetes (T2D). To choose the opt...

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Detalles Bibliográficos
Autores principales: Yokota, Harumasa, Hayashi, Hiroki, Hanaguri, Junya, Yamagami, Satoru, Kushiyama, Akifumi, Nakagami, Hironori, Nagaoka, Taiji
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8765632/
https://www.ncbi.nlm.nih.gov/pubmed/35041699
http://dx.doi.org/10.1371/journal.pone.0262568