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Mitochondrial genome sequencing of marine leukaemias reveals cancer contagion between clam species in the Seas of Southern Europe

Clonally transmissible cancers are tumour lineages that are transmitted between individuals via the transfer of living cancer cells. In marine bivalves, leukaemia-like transmissible cancers, called hemic neoplasia (HN), have demonstrated the ability to infect individuals from different species. We p...

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Autores principales: Garcia-Souto, Daniel, Bruzos, Alicia L, Diaz, Seila, Rocha, Sara, Pequeño-Valtierra, Ana, Roman-Lewis, Camila F, Alonso, Juana, Rodriguez, Rosana, Costas, Damian, Rodriguez-Castro, Jorge, Villanueva, Antonio, Silva, Luis, Valencia, Jose Maria, Annona, Giovanni, Tarallo, Andrea, Ricardo, Fernando, Bratoš Cetinić, Ana, Posada, David, Pasantes, Juan Jose, Tubio, Jose MC
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8765752/
https://www.ncbi.nlm.nih.gov/pubmed/35040778
http://dx.doi.org/10.7554/eLife.66946
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author Garcia-Souto, Daniel
Bruzos, Alicia L
Diaz, Seila
Rocha, Sara
Pequeño-Valtierra, Ana
Roman-Lewis, Camila F
Alonso, Juana
Rodriguez, Rosana
Costas, Damian
Rodriguez-Castro, Jorge
Villanueva, Antonio
Silva, Luis
Valencia, Jose Maria
Annona, Giovanni
Tarallo, Andrea
Ricardo, Fernando
Bratoš Cetinić, Ana
Posada, David
Pasantes, Juan Jose
Tubio, Jose MC
author_facet Garcia-Souto, Daniel
Bruzos, Alicia L
Diaz, Seila
Rocha, Sara
Pequeño-Valtierra, Ana
Roman-Lewis, Camila F
Alonso, Juana
Rodriguez, Rosana
Costas, Damian
Rodriguez-Castro, Jorge
Villanueva, Antonio
Silva, Luis
Valencia, Jose Maria
Annona, Giovanni
Tarallo, Andrea
Ricardo, Fernando
Bratoš Cetinić, Ana
Posada, David
Pasantes, Juan Jose
Tubio, Jose MC
author_sort Garcia-Souto, Daniel
collection PubMed
description Clonally transmissible cancers are tumour lineages that are transmitted between individuals via the transfer of living cancer cells. In marine bivalves, leukaemia-like transmissible cancers, called hemic neoplasia (HN), have demonstrated the ability to infect individuals from different species. We performed whole-genome sequencing in eight warty venus clams that were diagnosed with HN, from two sampling points located more than 1000 nautical miles away in the Atlantic Ocean and the Mediterranean Sea Coasts of Spain. Mitochondrial genome sequencing analysis from neoplastic animals revealed the coexistence of haplotypes from two different clam species. Phylogenies estimated from mitochondrial and nuclear markers confirmed this leukaemia originated in striped venus clams and later transmitted to clams of the species warty venus, in which it survives as a contagious cancer. The analysis of mitochondrial and nuclear gene sequences supports all studied tumours belong to a single neoplastic lineage that spreads in the Seas of Southern Europe.
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spelling pubmed-87657522022-01-19 Mitochondrial genome sequencing of marine leukaemias reveals cancer contagion between clam species in the Seas of Southern Europe Garcia-Souto, Daniel Bruzos, Alicia L Diaz, Seila Rocha, Sara Pequeño-Valtierra, Ana Roman-Lewis, Camila F Alonso, Juana Rodriguez, Rosana Costas, Damian Rodriguez-Castro, Jorge Villanueva, Antonio Silva, Luis Valencia, Jose Maria Annona, Giovanni Tarallo, Andrea Ricardo, Fernando Bratoš Cetinić, Ana Posada, David Pasantes, Juan Jose Tubio, Jose MC eLife Cancer Biology Clonally transmissible cancers are tumour lineages that are transmitted between individuals via the transfer of living cancer cells. In marine bivalves, leukaemia-like transmissible cancers, called hemic neoplasia (HN), have demonstrated the ability to infect individuals from different species. We performed whole-genome sequencing in eight warty venus clams that were diagnosed with HN, from two sampling points located more than 1000 nautical miles away in the Atlantic Ocean and the Mediterranean Sea Coasts of Spain. Mitochondrial genome sequencing analysis from neoplastic animals revealed the coexistence of haplotypes from two different clam species. Phylogenies estimated from mitochondrial and nuclear markers confirmed this leukaemia originated in striped venus clams and later transmitted to clams of the species warty venus, in which it survives as a contagious cancer. The analysis of mitochondrial and nuclear gene sequences supports all studied tumours belong to a single neoplastic lineage that spreads in the Seas of Southern Europe. eLife Sciences Publications, Ltd 2022-01-18 /pmc/articles/PMC8765752/ /pubmed/35040778 http://dx.doi.org/10.7554/eLife.66946 Text en © 2022, Garcia-Souto et al https://creativecommons.org/licenses/by/4.0/This article is distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use and redistribution provided that the original author and source are credited.
spellingShingle Cancer Biology
Garcia-Souto, Daniel
Bruzos, Alicia L
Diaz, Seila
Rocha, Sara
Pequeño-Valtierra, Ana
Roman-Lewis, Camila F
Alonso, Juana
Rodriguez, Rosana
Costas, Damian
Rodriguez-Castro, Jorge
Villanueva, Antonio
Silva, Luis
Valencia, Jose Maria
Annona, Giovanni
Tarallo, Andrea
Ricardo, Fernando
Bratoš Cetinić, Ana
Posada, David
Pasantes, Juan Jose
Tubio, Jose MC
Mitochondrial genome sequencing of marine leukaemias reveals cancer contagion between clam species in the Seas of Southern Europe
title Mitochondrial genome sequencing of marine leukaemias reveals cancer contagion between clam species in the Seas of Southern Europe
title_full Mitochondrial genome sequencing of marine leukaemias reveals cancer contagion between clam species in the Seas of Southern Europe
title_fullStr Mitochondrial genome sequencing of marine leukaemias reveals cancer contagion between clam species in the Seas of Southern Europe
title_full_unstemmed Mitochondrial genome sequencing of marine leukaemias reveals cancer contagion between clam species in the Seas of Southern Europe
title_short Mitochondrial genome sequencing of marine leukaemias reveals cancer contagion between clam species in the Seas of Southern Europe
title_sort mitochondrial genome sequencing of marine leukaemias reveals cancer contagion between clam species in the seas of southern europe
topic Cancer Biology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8765752/
https://www.ncbi.nlm.nih.gov/pubmed/35040778
http://dx.doi.org/10.7554/eLife.66946
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