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Effectiveness of Repair of Aortic Coarctation in Neonates: A Long-Term experience

To evaluate early and long-term results of surgical treatment of aortic coarctation (CoAo) in neonates. This is a retrospective clinical review of neonates with CoAo, who underwent surgery between 1995 and 2019. Data were retrieved from our institutional database, to identify preoperative and postop...

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Autores principales: Minotti, Chiara, Scioni, Manuela, Castaldi, Biagio, Guariento, Alvise, Biffanti, Roberta, Di Salvo, Giovanni, Vida, Vladimiro, Padalino, Massimo A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer US 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8766375/
https://www.ncbi.nlm.nih.gov/pubmed/34341850
http://dx.doi.org/10.1007/s00246-021-02685-z
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author Minotti, Chiara
Scioni, Manuela
Castaldi, Biagio
Guariento, Alvise
Biffanti, Roberta
Di Salvo, Giovanni
Vida, Vladimiro
Padalino, Massimo A.
author_facet Minotti, Chiara
Scioni, Manuela
Castaldi, Biagio
Guariento, Alvise
Biffanti, Roberta
Di Salvo, Giovanni
Vida, Vladimiro
Padalino, Massimo A.
author_sort Minotti, Chiara
collection PubMed
description To evaluate early and long-term results of surgical treatment of aortic coarctation (CoAo) in neonates. This is a retrospective clinical review of neonates with CoAo, who underwent surgery between 1995 and 2019. Data were retrieved from our institutional database, to identify preoperative and postoperative characteristics. Statistical analysis was performed by means of relative risk ratio and Cox and logistic multivariate analysis. 218 consecutive neonates (M/F: 129/89, median age 11 days, IQR 7–17 days) were included; 202 (92.7%) had a left thoracotomy; 178 underwent extended end-to-end anastomosis (EEEA, 81.6%). Hypoplastic aortic arch (HAA) was present in 102 patients (46.8%); complex cardiac anomalies in 85 (39%). Significant postoperative complications occurred in 20 (9.2%). Thirty-day mortality was 2.3% (most in complex types). At a median follow-up of 10.4 years (IQR 5.6–15.0 years; FU completeness 95.9%), there were 8 late deaths (3.7%), all associated to complex CoAo. Among 196 survivors, 177 (93.2%) were in NYHA class I; re-interventions on aortic arch occurred in 9.2% (2.0% were surgical). Freedom from mortality and re-intervention on aorta at 10 years were 94.3% and 96.7%, respectively. Surgical repair of CoAo in newborns without CPB in our series was safe and low-risk, with excellent early and late outcomes.
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spelling pubmed-87663752022-01-31 Effectiveness of Repair of Aortic Coarctation in Neonates: A Long-Term experience Minotti, Chiara Scioni, Manuela Castaldi, Biagio Guariento, Alvise Biffanti, Roberta Di Salvo, Giovanni Vida, Vladimiro Padalino, Massimo A. Pediatr Cardiol Original Article To evaluate early and long-term results of surgical treatment of aortic coarctation (CoAo) in neonates. This is a retrospective clinical review of neonates with CoAo, who underwent surgery between 1995 and 2019. Data were retrieved from our institutional database, to identify preoperative and postoperative characteristics. Statistical analysis was performed by means of relative risk ratio and Cox and logistic multivariate analysis. 218 consecutive neonates (M/F: 129/89, median age 11 days, IQR 7–17 days) were included; 202 (92.7%) had a left thoracotomy; 178 underwent extended end-to-end anastomosis (EEEA, 81.6%). Hypoplastic aortic arch (HAA) was present in 102 patients (46.8%); complex cardiac anomalies in 85 (39%). Significant postoperative complications occurred in 20 (9.2%). Thirty-day mortality was 2.3% (most in complex types). At a median follow-up of 10.4 years (IQR 5.6–15.0 years; FU completeness 95.9%), there were 8 late deaths (3.7%), all associated to complex CoAo. Among 196 survivors, 177 (93.2%) were in NYHA class I; re-interventions on aortic arch occurred in 9.2% (2.0% were surgical). Freedom from mortality and re-intervention on aorta at 10 years were 94.3% and 96.7%, respectively. Surgical repair of CoAo in newborns without CPB in our series was safe and low-risk, with excellent early and late outcomes. Springer US 2021-08-02 2022 /pmc/articles/PMC8766375/ /pubmed/34341850 http://dx.doi.org/10.1007/s00246-021-02685-z Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Original Article
Minotti, Chiara
Scioni, Manuela
Castaldi, Biagio
Guariento, Alvise
Biffanti, Roberta
Di Salvo, Giovanni
Vida, Vladimiro
Padalino, Massimo A.
Effectiveness of Repair of Aortic Coarctation in Neonates: A Long-Term experience
title Effectiveness of Repair of Aortic Coarctation in Neonates: A Long-Term experience
title_full Effectiveness of Repair of Aortic Coarctation in Neonates: A Long-Term experience
title_fullStr Effectiveness of Repair of Aortic Coarctation in Neonates: A Long-Term experience
title_full_unstemmed Effectiveness of Repair of Aortic Coarctation in Neonates: A Long-Term experience
title_short Effectiveness of Repair of Aortic Coarctation in Neonates: A Long-Term experience
title_sort effectiveness of repair of aortic coarctation in neonates: a long-term experience
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8766375/
https://www.ncbi.nlm.nih.gov/pubmed/34341850
http://dx.doi.org/10.1007/s00246-021-02685-z
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