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Nuclear and mitochondrial DNA editing in human cells with zinc finger deaminases

Base editing in nuclear DNA and mitochondrial DNA (mtDNA) is broadly useful for biomedical research, medicine, and biotechnology. Here, we present a base editing platform, termed zinc finger deaminases (ZFDs), composed of custom-designed zinc-finger DNA-binding proteins, the split interbacterial tox...

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Detalles Bibliográficos
Autores principales:	Lim, Kayeong, Cho, Sung-Ik, Kim, Jin-Soo
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8766470/ https://www.ncbi.nlm.nih.gov/pubmed/35042880 http://dx.doi.org/10.1038/s41467-022-27962-0

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