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Deficient or R273H and R248W Mutations of p53 Promote Chemoresistance to 5-FU via TCF21/CD44 Axis-Mediated Enhanced Stemness in Colorectal Carcinoma

Background: p53 mutations are highly frequent in various human cancers and are reported to contribute to tumor malignance and chemoresistance. In this study, we explored the mechanism by which mutant p53 promotes carcinogenesis and chemoresistance and provided novel insights into cancer therapy. Mat...

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Detalles Bibliográficos
Autores principales:	Gao, Xiaolei, Zheng, Xuan, Zhang, Yixin, Dong, Liying, Sun, Liangjie, Zhao, Na, Ding, Chong, Ma, Zeyun, Wang, Yixiang
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2022
Materias:	Cell and Developmental Biology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8766496/ https://www.ncbi.nlm.nih.gov/pubmed/35071232 http://dx.doi.org/10.3389/fcell.2021.788331

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