HER3 activation contributes toward the emergence of ALK inhibitor-tolerant cells in ALK-rearranged lung cancer with mesenchymal features

Anaplastic lymphoma kinase-tyrosine kinase inhibitors (ALK-TKIs) have shown dramatic efficacy in patients with ALK-rearranged lung cancer; however, complete response in these patients is rare. Here, we investigated the molecular mechanisms underlying the emergence and maintenance of drug-tolerant ce...

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Detalles Bibliográficos
Autores principales: Tanimura, Keiko, Yamada, Tadaaki, Okada, Koutaroh, Nakai, Kunihiro, Horinaka, Mano, Katayama, Yuki, Morimoto, Kenji, Ogura, Yuri, Takeda, Takayuki, Shiotsu, Shinsuke, Ichikawa, Kosuke, Watanabe, Satoshi, Morimoto, Yoshie, Iwasaku, Masahiro, Kaneko, Yoshiko, Uchino, Junji, Taniguchi, Hirokazu, Yoneda, Kazue, Matoba, Satoaki, Sakai, Toshiyuki, Uehara, Hisanori, Yano, Seiji, Kusaba, Tetsuro, Katayama, Ryohei, Takayama, Koichi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8766605/
https://www.ncbi.nlm.nih.gov/pubmed/35042943
http://dx.doi.org/10.1038/s41698-021-00250-8

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