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Retrospective analysis of the incidence of neurodegenerative disorders in idiopathic rapid eye movement sleep behavior disorder: a preliminary study in Japanese patients

OBJECTIVES: Idiopathic rapid eye movement (REM) sleep behavior disorder (iRBD) is characterized by abnormal and potentially violent behaviors during REM sleep, typically observed in older adult subjects. Previous reports have described a high risk for neurodegeneration in patients with iRBD; however...

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Autores principales: Kumagai, Reiko, Kitajima, Tsuyoshi, Hirose, Marina, Iwata, Nakao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Fujita Medical Society 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8766648/
https://www.ncbi.nlm.nih.gov/pubmed/35111522
http://dx.doi.org/10.20407/fmj.2019-011
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author Kumagai, Reiko
Kitajima, Tsuyoshi
Hirose, Marina
Iwata, Nakao
author_facet Kumagai, Reiko
Kitajima, Tsuyoshi
Hirose, Marina
Iwata, Nakao
author_sort Kumagai, Reiko
collection PubMed
description OBJECTIVES: Idiopathic rapid eye movement (REM) sleep behavior disorder (iRBD) is characterized by abnormal and potentially violent behaviors during REM sleep, typically observed in older adult subjects. Previous reports have described a high risk for neurodegeneration in patients with iRBD; however, to date, no published study has analyzed an adequate number of Japanese patients. We retrospectively analyzed the incidence of neurodegenerative disorders among patients diagnosed with iRBD in our department. METHODS: The data were retrospectively collected from patients’ medical records. The patients included in the study were diagnosed with iRBD using polysomnography in our department, from May 1, 2005 to November 30, 2018, with a follow-up of ≥6 months. Using the Kaplan–Meier (KM) method, we estimated the incidence of later diagnoses of neurodegenerative disorders among this cohort of patients with iRBD. RESULTS: Among 57 consecutive patients diagnosed with iRBD, 14 (24.6%) were later diagnosed with neurodegenerative disorders. Using the KM method, we estimated that the incidence was as high as 18.5% and 68.1% at 5 and 10 years, respectively. Of the 14 patients who developed neurodegenerative disorders, 12 (85.7%) had α-synucleinopathies (Parkinson’s disease in eight patients, Lewy body dementia in three, Alzheimer’s-type dementia in two, and multiple system atrophy in one). CONCLUSIONS: The results of this study suggest the high likelihood that iRBD may subsequently progress to neurodegenerative disorders in Japanese patients, a finding similar to those previously reported by studies performed overseas. Further studies using standardized prospective evaluation methods must be performed in Japan.
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spelling pubmed-87666482022-02-01 Retrospective analysis of the incidence of neurodegenerative disorders in idiopathic rapid eye movement sleep behavior disorder: a preliminary study in Japanese patients Kumagai, Reiko Kitajima, Tsuyoshi Hirose, Marina Iwata, Nakao Fujita Med J Original Article OBJECTIVES: Idiopathic rapid eye movement (REM) sleep behavior disorder (iRBD) is characterized by abnormal and potentially violent behaviors during REM sleep, typically observed in older adult subjects. Previous reports have described a high risk for neurodegeneration in patients with iRBD; however, to date, no published study has analyzed an adequate number of Japanese patients. We retrospectively analyzed the incidence of neurodegenerative disorders among patients diagnosed with iRBD in our department. METHODS: The data were retrospectively collected from patients’ medical records. The patients included in the study were diagnosed with iRBD using polysomnography in our department, from May 1, 2005 to November 30, 2018, with a follow-up of ≥6 months. Using the Kaplan–Meier (KM) method, we estimated the incidence of later diagnoses of neurodegenerative disorders among this cohort of patients with iRBD. RESULTS: Among 57 consecutive patients diagnosed with iRBD, 14 (24.6%) were later diagnosed with neurodegenerative disorders. Using the KM method, we estimated that the incidence was as high as 18.5% and 68.1% at 5 and 10 years, respectively. Of the 14 patients who developed neurodegenerative disorders, 12 (85.7%) had α-synucleinopathies (Parkinson’s disease in eight patients, Lewy body dementia in three, Alzheimer’s-type dementia in two, and multiple system atrophy in one). CONCLUSIONS: The results of this study suggest the high likelihood that iRBD may subsequently progress to neurodegenerative disorders in Japanese patients, a finding similar to those previously reported by studies performed overseas. Further studies using standardized prospective evaluation methods must be performed in Japan. Fujita Medical Society 2020 2020-02-11 /pmc/articles/PMC8766648/ /pubmed/35111522 http://dx.doi.org/10.20407/fmj.2019-011 Text en https://creativecommons.org/licenses/by/4.0/This is an Open access article distributed under the Terms of Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author(s) and source are credited.
spellingShingle Original Article
Kumagai, Reiko
Kitajima, Tsuyoshi
Hirose, Marina
Iwata, Nakao
Retrospective analysis of the incidence of neurodegenerative disorders in idiopathic rapid eye movement sleep behavior disorder: a preliminary study in Japanese patients
title Retrospective analysis of the incidence of neurodegenerative disorders in idiopathic rapid eye movement sleep behavior disorder: a preliminary study in Japanese patients
title_full Retrospective analysis of the incidence of neurodegenerative disorders in idiopathic rapid eye movement sleep behavior disorder: a preliminary study in Japanese patients
title_fullStr Retrospective analysis of the incidence of neurodegenerative disorders in idiopathic rapid eye movement sleep behavior disorder: a preliminary study in Japanese patients
title_full_unstemmed Retrospective analysis of the incidence of neurodegenerative disorders in idiopathic rapid eye movement sleep behavior disorder: a preliminary study in Japanese patients
title_short Retrospective analysis of the incidence of neurodegenerative disorders in idiopathic rapid eye movement sleep behavior disorder: a preliminary study in Japanese patients
title_sort retrospective analysis of the incidence of neurodegenerative disorders in idiopathic rapid eye movement sleep behavior disorder: a preliminary study in japanese patients
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8766648/
https://www.ncbi.nlm.nih.gov/pubmed/35111522
http://dx.doi.org/10.20407/fmj.2019-011
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