Functional Analysis of Variants in Complement Factor I Identified in Age-Related Macular Degeneration and Atypical Hemolytic Uremic Syndrome

Complement factor I (FI) is a central inhibitor of the complement system, and impaired FI function increases complement activation, contributing to diseases such as age-related macular degeneration (AMD) and atypical hemolytic uremic syndrome (aHUS). Genetic variation in complement factor I (CFI) ha...

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Detalles Bibliográficos
Autores principales: de Jong, Sarah, de Breuk, Anita, Bakker, Bjorn, Katti, Suresh, Hoyng, Carel B., Nilsson, Sara C., Blom, Anna M., van den Heuvel, Lambert P., den Hollander, Anneke I., Volokhina, Elena B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8766660/
https://www.ncbi.nlm.nih.gov/pubmed/35069568
http://dx.doi.org/10.3389/fimmu.2021.789897

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