The Impact of Oxidative Stress in Male Infertility

At present infertility is affecting about 15% of couples and male factor is responsible for almost 50% of infertility cases. Oxidative stress, due to enhanced Reactive Oxygen Species (ROS) production and/or decreased antioxidants, has been repeatedly suggested as a new emerging causative factor of t...

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Autores principales: Mannucci, Amanda, Argento, Flavia Rita, Fini, Eleonora, Coccia, Maria Elisabetta, Taddei, Niccolò, Becatti, Matteo, Fiorillo, Claudia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Molecular Biosciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8766739/
https://www.ncbi.nlm.nih.gov/pubmed/35071326
http://dx.doi.org/10.3389/fmolb.2021.799294
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author Mannucci, Amanda
Argento, Flavia Rita
Fini, Eleonora
Coccia, Maria Elisabetta
Taddei, Niccolò
Becatti, Matteo
Fiorillo, Claudia
author_facet Mannucci, Amanda
Argento, Flavia Rita
Fini, Eleonora
Coccia, Maria Elisabetta
Taddei, Niccolò
Becatti, Matteo
Fiorillo, Claudia
author_sort Mannucci, Amanda
collection PubMed
description At present infertility is affecting about 15% of couples and male factor is responsible for almost 50% of infertility cases. Oxidative stress, due to enhanced Reactive Oxygen Species (ROS) production and/or decreased antioxidants, has been repeatedly suggested as a new emerging causative factor of this condition. However, the central roles exerted by ROS in sperm physiology cannot be neglected. On these bases, the present review is focused on illustrating both the role of ROS in male infertility and their main sources of production. Oxidative stress assessment, the clinical use of redox biomarkers and the treatment of oxidative stress-related male infertility are also discussed.
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spelling pubmed-87667392022-01-20 The Impact of Oxidative Stress in Male Infertility Mannucci, Amanda Argento, Flavia Rita Fini, Eleonora Coccia, Maria Elisabetta Taddei, Niccolò Becatti, Matteo Fiorillo, Claudia Front Mol Biosci Molecular Biosciences At present infertility is affecting about 15% of couples and male factor is responsible for almost 50% of infertility cases. Oxidative stress, due to enhanced Reactive Oxygen Species (ROS) production and/or decreased antioxidants, has been repeatedly suggested as a new emerging causative factor of this condition. However, the central roles exerted by ROS in sperm physiology cannot be neglected. On these bases, the present review is focused on illustrating both the role of ROS in male infertility and their main sources of production. Oxidative stress assessment, the clinical use of redox biomarkers and the treatment of oxidative stress-related male infertility are also discussed. Frontiers Media S.A. 2022-01-05 /pmc/articles/PMC8766739/ /pubmed/35071326 http://dx.doi.org/10.3389/fmolb.2021.799294 Text en Copyright © 2022 Mannucci, Argento, Fini, Coccia, Taddei, Becatti and Fiorillo. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Molecular Biosciences
Mannucci, Amanda
Argento, Flavia Rita
Fini, Eleonora
Coccia, Maria Elisabetta
Taddei, Niccolò
Becatti, Matteo
Fiorillo, Claudia
The Impact of Oxidative Stress in Male Infertility
title The Impact of Oxidative Stress in Male Infertility
title_full The Impact of Oxidative Stress in Male Infertility
title_fullStr The Impact of Oxidative Stress in Male Infertility
title_full_unstemmed The Impact of Oxidative Stress in Male Infertility
title_short The Impact of Oxidative Stress in Male Infertility
title_sort impact of oxidative stress in male infertility
topic Molecular Biosciences
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8766739/
https://www.ncbi.nlm.nih.gov/pubmed/35071326
http://dx.doi.org/10.3389/fmolb.2021.799294
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