Cargando…

Salivary Exosomes: From Waste to Promising Periodontitis Treatment

Periodontitis is a chronic inflammatory condition that causes tooth loss by destroying the supporting components of the teeth. In most cases, it is difficult to diagnose early and results in severe phases of the disease. Given their endogenous origins, exosomes, which are rich in peptides, lipids, a...

Descripción completa

Detalles Bibliográficos
Autores principales: Nik Mohamed Kamal, Nik Nur Syazana, Shahidan, Wan Nazatul Shima
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8766748/
https://www.ncbi.nlm.nih.gov/pubmed/35069258
http://dx.doi.org/10.3389/fphys.2021.798682
_version_ 1784634592384253952
author Nik Mohamed Kamal, Nik Nur Syazana
Shahidan, Wan Nazatul Shima
author_facet Nik Mohamed Kamal, Nik Nur Syazana
Shahidan, Wan Nazatul Shima
author_sort Nik Mohamed Kamal, Nik Nur Syazana
collection PubMed
description Periodontitis is a chronic inflammatory condition that causes tooth loss by destroying the supporting components of the teeth. In most cases, it is difficult to diagnose early and results in severe phases of the disease. Given their endogenous origins, exosomes, which are rich in peptides, lipids, and nucleic acids, have emerged as a cell-free therapeutic approach with low immunogenicity and increased safety. Because the constituents of exosomes can be reprogrammed depending on disease states, exosomes are increasingly being evaluated to act as potential diagnostic biomarkers for dental disease, including periodontitis. Exosomes also have been demonstrated to be involved in inflammatory signal transmission and periodontitis progression in vitro, indicating that they could be used as therapeutic targets for periodontal regeneration. Nevertheless, a review on the involvement of salivary exosomes in periodontitis in impacting the successful diagnosis and treatment of periodontitis is still lacking in the literature. Thus, this review is intended to scrutinize recent advancements of salivary exosomes in periodontitis treatment. We summarize recent research reports on the emerging roles and characteristics of salivary exosomes, emphasizing the different expressions and changed biological roles of exosomes in periodontitis.
format Online
Article
Text
id pubmed-8766748
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher Frontiers Media S.A.
record_format MEDLINE/PubMed
spelling pubmed-87667482022-01-20 Salivary Exosomes: From Waste to Promising Periodontitis Treatment Nik Mohamed Kamal, Nik Nur Syazana Shahidan, Wan Nazatul Shima Front Physiol Physiology Periodontitis is a chronic inflammatory condition that causes tooth loss by destroying the supporting components of the teeth. In most cases, it is difficult to diagnose early and results in severe phases of the disease. Given their endogenous origins, exosomes, which are rich in peptides, lipids, and nucleic acids, have emerged as a cell-free therapeutic approach with low immunogenicity and increased safety. Because the constituents of exosomes can be reprogrammed depending on disease states, exosomes are increasingly being evaluated to act as potential diagnostic biomarkers for dental disease, including periodontitis. Exosomes also have been demonstrated to be involved in inflammatory signal transmission and periodontitis progression in vitro, indicating that they could be used as therapeutic targets for periodontal regeneration. Nevertheless, a review on the involvement of salivary exosomes in periodontitis in impacting the successful diagnosis and treatment of periodontitis is still lacking in the literature. Thus, this review is intended to scrutinize recent advancements of salivary exosomes in periodontitis treatment. We summarize recent research reports on the emerging roles and characteristics of salivary exosomes, emphasizing the different expressions and changed biological roles of exosomes in periodontitis. Frontiers Media S.A. 2022-01-05 /pmc/articles/PMC8766748/ /pubmed/35069258 http://dx.doi.org/10.3389/fphys.2021.798682 Text en Copyright © 2022 Nik Mohamed Kamal and Shahidan. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Physiology
Nik Mohamed Kamal, Nik Nur Syazana
Shahidan, Wan Nazatul Shima
Salivary Exosomes: From Waste to Promising Periodontitis Treatment
title Salivary Exosomes: From Waste to Promising Periodontitis Treatment
title_full Salivary Exosomes: From Waste to Promising Periodontitis Treatment
title_fullStr Salivary Exosomes: From Waste to Promising Periodontitis Treatment
title_full_unstemmed Salivary Exosomes: From Waste to Promising Periodontitis Treatment
title_short Salivary Exosomes: From Waste to Promising Periodontitis Treatment
title_sort salivary exosomes: from waste to promising periodontitis treatment
topic Physiology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8766748/
https://www.ncbi.nlm.nih.gov/pubmed/35069258
http://dx.doi.org/10.3389/fphys.2021.798682
work_keys_str_mv AT nikmohamedkamalniknursyazana salivaryexosomesfromwastetopromisingperiodontitistreatment
AT shahidanwannazatulshima salivaryexosomesfromwastetopromisingperiodontitistreatment