Dendriplex-Impregnated Hydrogels With Programmed Release Rate

Hydrogels are biocompatible matrices for local delivery of nucleic acids; however, functional dopants are required to provide efficient delivery into cells. In particular, dendrimers, known as robust nucleic acid carriers, can be used as dopants. Herein, we report the first example of impregnating n...

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Detalles Bibliográficos
Autores principales: Apartsin, Evgeny, Venyaminova, Alya, Majoral, Jean-Pierre, Caminade, Anne-Marie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8766751/
https://www.ncbi.nlm.nih.gov/pubmed/35071182
http://dx.doi.org/10.3389/fchem.2021.780608
Descripción
Sumario:Hydrogels are biocompatible matrices for local delivery of nucleic acids; however, functional dopants are required to provide efficient delivery into cells. In particular, dendrimers, known as robust nucleic acid carriers, can be used as dopants. Herein, we report the first example of impregnating neutral hydrogels with siRNA–dendrimer complexes. The surface chemistry of dendrimers allows adjusting the release rate of siRNA-containing complexes. This methodology can bring new materials for biomedical applications.

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