Dendriplex-Impregnated Hydrogels With Programmed Release Rate

Hydrogels are biocompatible matrices for local delivery of nucleic acids; however, functional dopants are required to provide efficient delivery into cells. In particular, dendrimers, known as robust nucleic acid carriers, can be used as dopants. Herein, we report the first example of impregnating n...

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Autores principales: Apartsin, Evgeny, Venyaminova, Alya, Majoral, Jean-Pierre, Caminade, Anne-Marie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8766751/
https://www.ncbi.nlm.nih.gov/pubmed/35071182
http://dx.doi.org/10.3389/fchem.2021.780608
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author Apartsin, Evgeny
Venyaminova, Alya
Majoral, Jean-Pierre
Caminade, Anne-Marie
author_facet Apartsin, Evgeny
Venyaminova, Alya
Majoral, Jean-Pierre
Caminade, Anne-Marie
author_sort Apartsin, Evgeny
collection PubMed
description Hydrogels are biocompatible matrices for local delivery of nucleic acids; however, functional dopants are required to provide efficient delivery into cells. In particular, dendrimers, known as robust nucleic acid carriers, can be used as dopants. Herein, we report the first example of impregnating neutral hydrogels with siRNA–dendrimer complexes. The surface chemistry of dendrimers allows adjusting the release rate of siRNA-containing complexes. This methodology can bring new materials for biomedical applications.
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spelling pubmed-87667512022-01-20 Dendriplex-Impregnated Hydrogels With Programmed Release Rate Apartsin, Evgeny Venyaminova, Alya Majoral, Jean-Pierre Caminade, Anne-Marie Front Chem Chemistry Hydrogels are biocompatible matrices for local delivery of nucleic acids; however, functional dopants are required to provide efficient delivery into cells. In particular, dendrimers, known as robust nucleic acid carriers, can be used as dopants. Herein, we report the first example of impregnating neutral hydrogels with siRNA–dendrimer complexes. The surface chemistry of dendrimers allows adjusting the release rate of siRNA-containing complexes. This methodology can bring new materials for biomedical applications. Frontiers Media S.A. 2022-01-05 /pmc/articles/PMC8766751/ /pubmed/35071182 http://dx.doi.org/10.3389/fchem.2021.780608 Text en Copyright © 2022 Apartsin, Venyaminova, Majoral and Caminade. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Chemistry
Apartsin, Evgeny
Venyaminova, Alya
Majoral, Jean-Pierre
Caminade, Anne-Marie
Dendriplex-Impregnated Hydrogels With Programmed Release Rate
title Dendriplex-Impregnated Hydrogels With Programmed Release Rate
title_full Dendriplex-Impregnated Hydrogels With Programmed Release Rate
title_fullStr Dendriplex-Impregnated Hydrogels With Programmed Release Rate
title_full_unstemmed Dendriplex-Impregnated Hydrogels With Programmed Release Rate
title_short Dendriplex-Impregnated Hydrogels With Programmed Release Rate
title_sort dendriplex-impregnated hydrogels with programmed release rate
topic Chemistry
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8766751/
https://www.ncbi.nlm.nih.gov/pubmed/35071182
http://dx.doi.org/10.3389/fchem.2021.780608
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