Single-Cell Transcriptomes Combining with Consecutive Genomics Reveal Clonal Evolution and Gene Regulatory Networks in Relapsed and Refractory Multiple Myeloma

This study attempted to investigate how clonal structure evolves, along with potential regulatory networks, as a result of multiline therapies in relapsed/refractory multiple myeloma (RRMM). Eight whole exome sequencing (WES) and one single cell RNA sequencing (scRNA-seq) were performed in order to...

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Detalles Bibliográficos
Autores principales: Xu, Jiadai, Wang, Yue, Wei, Zheng, Zhuang, Jingli, Li, Jing, Sun, Yifeng, Ren, Liang, Wang, Yawen, Li, Panpan, Gu, Shiyang, Zhang, Yian, Jiang, Jifeng, Chen, Chen, Zhang, Yu, Liu, Peng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Cell and Developmental Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8766805/
https://www.ncbi.nlm.nih.gov/pubmed/35071234
http://dx.doi.org/10.3389/fcell.2021.794144

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