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Discovery of Small Molecule NSC290956 as a Therapeutic Agent for KRas Mutant Non-Small-Cell Lung Cancer

HRas-GTP has a transient intermediate state with a “non-signaling open conformation” in GTP hydrolysis and nucleotide exchange. Due to the same hydrolysis process and the structural homology, it can be speculated that the active KRas adopts the same characteristics with the “open conformation.” This...

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Detalles Bibliográficos
Autores principales:	Zhang, Jiaxin, Liu, Zuojia, Zhao, Wenjing, Yin, Xunzhe, Zheng, Xiliang, Liu, Chuanbo, Wang, Jin, Wang, Erkang
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2022
Materias:	Pharmacology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8766838/ https://www.ncbi.nlm.nih.gov/pubmed/35069209 http://dx.doi.org/10.3389/fphar.2021.797821

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