A novel STING agonist-adjuvanted pan-sarbecovirus vaccine elicits potent and durable neutralizing antibody and T cell responses in mice, rabbits and NHPs

The emergence of SARS-CoV-2 variants and potentially other highly pathogenic sarbecoviruses in the future highlights the need for pan-sarbecovirus vaccines. Here, we discovered a new STING agonist, CF501, and found that CF501-adjuvanted RBD-Fc vaccine (CF501/RBD-Fc) elicited significantly stronger n...

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Detalles Bibliográficos
Autores principales: Liu, Zezhong, Zhou, Jie, Xu, Wei, Deng, Wei, Wang, Yanqun, Wang, Meiyu, Wang, Qian, Hsieh, Ming, Dong, Jingming, Wang, Xinling, Huang, Weijin, Xing, Lixiao, He, Miaoling, Tao, Chunlin, Xie, Youhua, Zhang, Yilong, Wang, Youchun, Zhao, Jincun, Yuan, Zhenghong, Qin, Chuan, Jiang, Shibo, Lu, Lu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Singapore 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8767042/
https://www.ncbi.nlm.nih.gov/pubmed/35046518
http://dx.doi.org/10.1038/s41422-022-00612-2

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