TGFβ2 Induces the Soluble Isoform of CTLA-4 – Implications for CTLA-4 Based Checkpoint Inhibitor Antibodies in Malignant Melanoma

Malignant melanoma is an aggressive form of cancer, which can be treated with anti-CTLA-4 and anti-PD-1 checkpoint inhibitor antibodies but while anti-CTLA-4 antibodies have clear benefits for some patients with melanoma, productive responses are difficult to predict and often associated with seriou...

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Detalles Bibliográficos
Autores principales: Khanolkar, Rahul C., Zhang, Chu, Al-Fatyan, Farah, Lawson, Linda, Depasquale, Ivan, Meredith, Fiona M., Muller, Frank, Nicolson, Marianne, Dahal, Lekh Nath, Abu-Eid, Rasha, Rajpara, Sanjay, Barker, Robert Norman, Ormerod, Anthony D., Ward, Frank James
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8767111/
https://www.ncbi.nlm.nih.gov/pubmed/35069536
http://dx.doi.org/10.3389/fimmu.2021.763877

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