Multiparameter Optimization of Trypanocidal Cruzain Inhibitors With In Vivo Activity and Favorable Pharmacokinetics

Cruzain, the main cysteine protease of Trypanosoma cruzi, plays key roles in all stages of the parasite’s life cycle, including nutrition acquisition, differentiation, evasion of the host immune system, and invasion of host cells. Thus, inhibition of this validated target may lead to the development...

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Detalles Bibliográficos
Autores principales: Pauli, Ivani, Rezende Jr., Celso de O., Slafer, Brian W., Dessoy, Marco A., de Souza, Mariana L., Ferreira, Leonardo L. G., Adjanohun, Abraham L. M., Ferreira, Rafaela S., Magalhães, Luma G., Krogh, Renata, Michelan-Duarte, Simone, Del Pintor, Ricardo Vaz, da Silva, Fernando B. R., Cruz, Fabio C., Dias, Luiz C., Andricopulo, Adriano D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8767159/
https://www.ncbi.nlm.nih.gov/pubmed/35069198
http://dx.doi.org/10.3389/fphar.2021.774069

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