Mapping of a N-terminal α-helix domain required for human PINK1 stabilization, Serine228 autophosphorylation and activation in cells

Autosomal recessive mutations in the PINK1 gene are causal for Parkinson's disease (PD). PINK1 encodes a mitochondrial localized protein kinase that is a master-regulator of mitochondrial quality control pathways. Structural studies to date have elaborated the mechanism of how mutations located...

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Detalles Bibliográficos
Autores principales: Kakade, Poonam, Ojha, Hina, Raimi, Olawale G., Shaw, Andrew, Waddell, Andrew D., Ault, James R., Burel, Sophie, Brockmann, Kathrin, Kumar, Atul, Ahangar, Mohd Syed, Krysztofinska, Ewelina M., Macartney, Thomas, Bayliss, Richard, Fitzgerald, Julia C., Muqit, Miratul M. K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society 2022
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8767193/
https://www.ncbi.nlm.nih.gov/pubmed/35042401
http://dx.doi.org/10.1098/rsob.210264

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