Selective localization of Mfn2 near PINK1 enables its preferential ubiquitination by Parkin on mitochondria

Mutations in Parkin and PINK1 cause early-onset familial Parkinson's disease. Parkin is a RING-In-Between-RING E3 ligase that transfers ubiquitin from an E2 enzyme to a substrate in two steps: (i) thioester intermediate formation on Parkin and (ii) acyl transfer to a substrate lysine. The proce...

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Detalles Bibliográficos
Autores principales: Vranas, Marta, Lu, Yang, Rasool, Shafqat, Croteau, Nathalie, Krett, Jonathan D., Sauvé, Véronique, Gehring, Kalle, Fon, Edward A., Durcan, Thomas M., Trempe, Jean-François
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society 2022
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8767196/
https://www.ncbi.nlm.nih.gov/pubmed/35042405
http://dx.doi.org/10.1098/rsob.210255

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