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Anion binding to a cationic europium(iii) probe enables the first real-time assay of heparan sulfotransferase activity

Sulfotransferases constitute a ubiquitous class of enzymes which are poorly understood due to the lack of a convenient tool for screening their activity. These enzymes use the anion PAPS (adenosine-3′-phosphate-5′-phosphosulfate) as a donor for a broad range of acceptor substrates, including carbohy...

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Detalles Bibliográficos
Autores principales: Wheeler, Simon, Breen, Colum, Li, Yong, Hewitt, Sarah H., Robertson, Erin, Yates, Edwin A., Barsukov, Igor L., Fernig, David G., Butler, Stephen J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8767414/
https://www.ncbi.nlm.nih.gov/pubmed/34951618
http://dx.doi.org/10.1039/d1ob02071d

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