Bromodomain and extraterminal (BET) protein inhibitor, apabetalone, reduces ACE2 expression and attenuates SARS-CoV-2 infection in vitro

BACKGROUND/INTRODUCTION: SARS-CoV-2 causes life threatening COVID-19 complications including acute coronary syndrome, venous thromboembolism, hyperinflammation and damage in multiple tissues. The SARS-CoV-2 “spike protein” binds cell surface receptors including angiotensin-converting enzyme 2 (ACE2)...

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Detalles Bibliográficos
Autores principales: Gilham, D, Smith, A L, Fu, L, Moore, D Y, Muralidharan, A, Reid, S P M, Stotz, S C, Johansson, J O, Sweeney, M, Wong, N C W, El-Gamal, D, Kulikowski, E
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2021
Materias:
Abstract Supplement
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8767620/
http://dx.doi.org/10.1093/eurheartj/ehab724.3267

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