Cargando…

Penfluridol targets acid sphingomyelinase to inhibit TNF signaling and is therapeutic against inflammatory autoimmune diseases

BACKGROUND: Penfluridol, isolated from an FDA-approved small-molecule drug library as an inhibitor of tumor necrosis factor α (TNFα)-stimulated NF-κB activation, is clinically used to treat chronic schizophrenia and related disorders. This study is aimed to investigate the therapeutic effect of penf...

Descripción completa

Detalles Bibliográficos
Autores principales:	Chen, Yue-hong, Liu, Rong-han, Cui, Ya-zhou, Hettinghouse, Aubryanna, Fu, Wen-yu, Zhang, Lei, Zhang, Chen, Liu, Chuan-ju
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2022
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8767691/ https://www.ncbi.nlm.nih.gov/pubmed/35045889 http://dx.doi.org/10.1186/s13075-021-02713-6

Ejemplares similares

Cytosolic Phospholipase A2 Is Required for Fexofenadine’s Therapeutic Effects against Inflammatory Bowel Disease in Mice
por: Zhao, Xiangli, et al.
Publicado: (2021)

Brain-penetrant heat shock protein amplifier arimoclomol enhances GCase activity in in vitro Gaucher disease models
por: Hettinghouse, Aubryanna, et al.
Publicado: (2018)

Progranulin acts as a shared chaperone and regulates multiple lysosomal enzymes
por: Jian, Jinlong, et al.
Publicado: (2017)

Antimicrobial, Antibiofilm, and Anti-persister Activities of Penfluridol Against Staphylococcus aureus
por: Liu, Yaqian, et al.
Publicado: (2021)

Drug repurposing: Antimicrobial and antibiofilm effects of penfluridol against Enterococcus faecalis
por: Zeng, Xianghai, et al.
Publicado: (2020)

Repurposing Penfluridol in Combination with Temozolomide for the Treatment of Glioblastoma
por: Kim, Hyungsin, et al.
Publicado: (2019)

Atsttrin Promotes Cartilage Repair Primarily Through TNFR2-Akt Pathway
por: Wei, Jianlu, et al.
Publicado: (2020)

Progranulin derivative Atsttrin protects against early osteoarthritis in mouse and rat models
por: Wei, Jian-lu, et al.
Publicado: (2017)

Progranulin deficiency exacerbates spinal cord injury by promoting neuroinflammation and cell apoptosis in mice
por: Wang, Chao, et al.
Publicado: (2019)

Progranulin Recruits HSP70 to β-Glucocerebrosidase and Is Therapeutic Against Gaucher Disease
por: Jian, Jinlong, et al.
Publicado: (2016)

PENFLURIDOL MAINTENANCE THERAPY IN SCHIZOPHRENIA: A CONTROLLED STUDY
por: Channabasavanna, S.M., et al.
Publicado: (1987)

Penfluridol overcomes paclitaxel resistance in metastatic breast cancer
por: Gupta, Nehal, et al.
Publicado: (2019)

Low Dose of Penfluridol Inhibits VEGF-Induced Angiogenesis
por: Srivastava, Suyash, et al.
Publicado: (2020)

Penfluridol as a Candidate of Drug Repurposing for Anticancer Agent
por: Tuan, Nguyen Minh, et al.
Publicado: (2019)

Penfluridol suppresses pancreatic tumor growth by autophagy-mediated apoptosis
por: Ranjan, Alok, et al.
Publicado: (2016)

Neutral sphingomyelinase 2 regulates inflammatory responses in monocytes/macrophages induced by TNF-α
por: Al-Rashed, Fatema, et al.
Publicado: (2020)

RNA-Seq analysis of interferon inducible p204-mediated network in anti-tumor immunity
por: Jian, Jinlong, et al.
Publicado: (2018)

Repurposing FDA-approved drugs for SARS-CoV-2 through an ELISA-based screening for the inhibition of RBD/ACE2 interaction
por: Fu, Wenyu, et al.
Publicado: (2020)

Immune consequences of penfluridol treatment associated with inhibition of glioblastoma tumor growth
por: Ranjan, Alok, et al.
Publicado: (2017)

Inhibition of AMPK/PFKFB3 mediated glycolysis synergizes with penfluridol to suppress gallbladder cancer growth
por: Hu, Jiahao, et al.
Publicado: (2022)

Penfluridol suppresses glioblastoma tumor growth by Akt-mediated inhibition of GLI1
por: Ranjan, Alok, et al.
Publicado: (2017)

Reevaluation of Lung Injury in TNF-Induced Shock: The Role of the Acid Sphingomyelinase
por: Reiss, Lucy K., et al.
Publicado: (2020)

Neutral sphingomyelinase-3 mediates TNF-stimulated oxidant activity in skeletal muscle
por: Moylan, Jennifer S., et al.
Publicado: (2014)

Synergistic Tumor Inhibition via Energy Elimination by Repurposing Penfluridol and 2-Deoxy-D-Glucose in Lung Cancer
por: Lai, Tsung-Ching, et al.
Publicado: (2022)

Compartimentalization of TNF-receptor 1 signalling: acid sphingomyelinase is activated by Caspase-8 in internalized TNF-R1 receptosomes
por: Edelmann, B, et al.
Publicado: (2009)

Targeting DRD2 by the antipsychotic drug, penfluridol, retards growth of renal cell carcinoma via inducing stemness inhibition and autophagy-mediated apoptosis
por: Tung, Min-Che, et al.
Publicado: (2022)

p204 Is Required for Canonical Lipopolysaccharide-induced TLR4 Signaling in Mice
por: Yi, Young-Su, et al.
Publicado: (2018)

Sphingomyelinases and Liver Diseases
por: Insausti-Urkia, Naroa, et al.
Publicado: (2020)

Extracellular sphingomyelinase activity impairs TNF-α-induced endothelial cell death via ADAM17 activation and TNF receptor 1 shedding
por: Sommer, Anselm, et al.
Publicado: (2017)

Targeting PFKL with penfluridol inhibits glycolysis and suppresses esophageal cancer tumorigenesis in an AMPK/FOXO3a/BIM-dependent manner
por: Zheng, Cancan, et al.
Publicado: (2022)

Targeting TNF and Its Family Members in Autoimmune/Inflammatory Disease
por: Desplat-Jégo, Sophie, et al.
Publicado: (2014)

Neutral sphingomyelinase-2, acid sphingomyelinase, and ceramide levels in COPD patients compared to controls
por: Lea, Simon R, et al.
Publicado: (2016)

Drugs for Autoimmune Inflammatory Diseases: From Small Molecule Compounds to Anti-TNF Biologics
por: Li, Ping, et al.
Publicado: (2017)

Acid sphingomyelinase deals the seal
por: Short, Ben
Publicado: (2010)

Therapeutic potential of TNFα inhibitors in chronic inflammatory disorders: Past and future
por: Zhang, Hongtao, et al.
Publicado: (2020)

Acid sphingomyelinase/ceramide system in schizophrenia: implications for therapeutic intervention as a potential novel target
por: Zhuo, Chuanjun, et al.
Publicado: (2022)

The Role of Tumor Necrosis Factor Alpha (TNF-α) in Autoimmune Disease and Current TNF-α Inhibitors in Therapeutics
por: Jang, Dan-in, et al.
Publicado: (2021)

Sphingomyelinase helps bones get their minerals
por: Short, Ben
Publicado: (2011)

Molecular modeling of human alkaline sphingomyelinase
por: Suresh, Panneer Selvam, et al.
Publicado: (2011)

Neutral Sphingomyelinase and Breast Cancer Research
por: Hwang, Sun-Yong, et al.
Publicado: (2015)

Cannot write session to /tmp/vufind_sessions/sess_l46hnro98t44l8hgcn79g7lj1l