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circFARP1 enables cancer-associated fibroblasts to promote gemcitabine resistance in pancreatic cancer via the LIF/STAT3 axis

BACKGROUND: Cancer-associated fibroblasts (CAFs) are critically involved in gemcitabine (GEM) resistance in pancreatic ductal adenocarcinoma (PDAC). However, the underlying mechanism by which CAFs promote chemotherapy resistance remains unexplored. Here, we explored the role of circRNAs in CAF-induc...

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Detalles Bibliográficos
Autores principales:	Hu, Chonghui, Xia, Renpeng, Zhang, Xiang, Li, Tingting, Ye, Yuancheng, Li, Guolin, He, Rihua, Li, Zhihua, Lin, Qing, Zheng, Shangyou, Chen, Rufu
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2022
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8767726/ https://www.ncbi.nlm.nih.gov/pubmed/35045883 http://dx.doi.org/10.1186/s12943-022-01501-3

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