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The potential role of COVID-19 in the induction of DNA damage

The coronavirus disease-2019 (COVID-19) caused by the severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) is challenging global health and economic systems. In some individuals, COVID-19 can cause a wide array of symptoms, affecting several organs, such as the lungs, heart, bowels, kidneys...

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Autores principales: Pánico, Pablo, Ostrosky-Wegman, Patricia, Salazar, Ana María
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier B.V. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8767986/
https://www.ncbi.nlm.nih.gov/pubmed/35690420
http://dx.doi.org/10.1016/j.mrrev.2022.108411
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author Pánico, Pablo
Ostrosky-Wegman, Patricia
Salazar, Ana María
author_facet Pánico, Pablo
Ostrosky-Wegman, Patricia
Salazar, Ana María
author_sort Pánico, Pablo
collection PubMed
description The coronavirus disease-2019 (COVID-19) caused by the severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) is challenging global health and economic systems. In some individuals, COVID-19 can cause a wide array of symptoms, affecting several organs, such as the lungs, heart, bowels, kidneys and brain, causing multiorgan failure, sepsis and death. These effects are related in part to direct viral infection of these organs, immunological deregulation, a hypercoagulatory state and the potential for development of cytokine storm syndrome. Since the appearance of COVID-19 is recent, the long-term effects on the health of recovered patients remain unknown. In this review, we focused on current evidence of the mechanisms of DNA damage mediated by coronaviruses. Data supports that these viruses can induce DNA damage, genomic instability, and cell cycle deregulation during their replication in mammalian cells. Since the induction of DNA damage and aberrant DNA repair mechanisms are related to the development of chronic diseases such as cancer, diabetes, neurodegenerative disorders, and atherosclerosis, it will be important to address similar effects and outcomes in recovered COVID-19 patients.
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spelling pubmed-87679862022-01-19 The potential role of COVID-19 in the induction of DNA damage Pánico, Pablo Ostrosky-Wegman, Patricia Salazar, Ana María Mutat Res Rev Mutat Res Article The coronavirus disease-2019 (COVID-19) caused by the severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) is challenging global health and economic systems. In some individuals, COVID-19 can cause a wide array of symptoms, affecting several organs, such as the lungs, heart, bowels, kidneys and brain, causing multiorgan failure, sepsis and death. These effects are related in part to direct viral infection of these organs, immunological deregulation, a hypercoagulatory state and the potential for development of cytokine storm syndrome. Since the appearance of COVID-19 is recent, the long-term effects on the health of recovered patients remain unknown. In this review, we focused on current evidence of the mechanisms of DNA damage mediated by coronaviruses. Data supports that these viruses can induce DNA damage, genomic instability, and cell cycle deregulation during their replication in mammalian cells. Since the induction of DNA damage and aberrant DNA repair mechanisms are related to the development of chronic diseases such as cancer, diabetes, neurodegenerative disorders, and atherosclerosis, it will be important to address similar effects and outcomes in recovered COVID-19 patients. Elsevier B.V. 2022 2022-01-19 /pmc/articles/PMC8767986/ /pubmed/35690420 http://dx.doi.org/10.1016/j.mrrev.2022.108411 Text en © 2022 Elsevier B.V. All rights reserved. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
spellingShingle Article
Pánico, Pablo
Ostrosky-Wegman, Patricia
Salazar, Ana María
The potential role of COVID-19 in the induction of DNA damage
title The potential role of COVID-19 in the induction of DNA damage
title_full The potential role of COVID-19 in the induction of DNA damage
title_fullStr The potential role of COVID-19 in the induction of DNA damage
title_full_unstemmed The potential role of COVID-19 in the induction of DNA damage
title_short The potential role of COVID-19 in the induction of DNA damage
title_sort potential role of covid-19 in the induction of dna damage
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8767986/
https://www.ncbi.nlm.nih.gov/pubmed/35690420
http://dx.doi.org/10.1016/j.mrrev.2022.108411
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