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Clinical and laboratory profile of systemic lupus erythematosus patients at a rural tertiary centre in South-South Nigeria: experience from a new rheumatology clinic
OBJECTIVES: Systemic lupus erythematosus (SLE) is an autoimmune disorder with a poorly understood aetiology. It predominantly affects females and has a variety of clinical manifestations. In Nigeria, there are limited data on the prevalence and burden of the disease. This study aimed to determine th...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Narodowy Instytut Geriatrii, Reumatologii i Rehabilitacji w Warszawie
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8768036/ https://www.ncbi.nlm.nih.gov/pubmed/35079185 http://dx.doi.org/10.5114/reum.2021.111714 |
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author | Emorinken, Airenakho Dic-Ijiewere, Mercy Ofunami Erameh, Cyril Oshomah Ugheoke, Asuwemhe Johnson Agbadaola, Oluwaseun Remi Agbebaku, Folasade Ojuolape |
author_facet | Emorinken, Airenakho Dic-Ijiewere, Mercy Ofunami Erameh, Cyril Oshomah Ugheoke, Asuwemhe Johnson Agbadaola, Oluwaseun Remi Agbebaku, Folasade Ojuolape |
author_sort | Emorinken, Airenakho |
collection | PubMed |
description | OBJECTIVES: Systemic lupus erythematosus (SLE) is an autoimmune disorder with a poorly understood aetiology. It predominantly affects females and has a variety of clinical manifestations. In Nigeria, there are limited data on the prevalence and burden of the disease. This study aimed to determine the clinical and laboratory profiles of SLE patients seen in a new rheumatology clinic in South-South Nigeria. MATERIAL AND METHODS: This was a retrospective cross-sectional study conducted over five years (January 2016 to December 2020). The case files of patients that satisfied the diagnosis of SLE were reviewed. The diagnosis was based on the 1997 update of the American College of Rheumatology revised criteria for the classification of SLE. The sociodemographic, clinical, and immunological data were extracted from case records. Data analysis was carried out using IBM SPSS statistics(®) 2012 version 21.0. RESULTS: Fifty-two patients were diagnosed with SLE, giving a frequency of 4.7%. Forty-seven (90.4%) of the study participants were females, with a female-to-male ratio of 9.4 : 1. The mean age of the study group was 28.42 years. The mean duration of disease before diagnosis was 4.04 months with a range of 1–15 months. The patients had various organ system manifestations, with polyarthritis being the commonest (86.5%). Others included mucocutaneous (78.8%), haematological (69.2%), serositis (40.4%), renal (38.5%), and neurological (25%) manifestations. Antinuclear antibody (ANA) assay and anti-double-stranded DNA were positive in 100% and 69.2% of patients, respectively. All patients were placed on steroids, and 96.2% had hydroxychloroquine. None of the patients were on biologic disease-modifying antirheumatic drugs. CONCLUSIONS: This study’s results are consistent with data from other African countries. To fully understand the burden and epidemiology of SLE in Nigeria, a larger prospective study is needed. |
format | Online Article Text |
id | pubmed-8768036 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Narodowy Instytut Geriatrii, Reumatologii i Rehabilitacji w Warszawie |
record_format | MEDLINE/PubMed |
spelling | pubmed-87680362022-01-24 Clinical and laboratory profile of systemic lupus erythematosus patients at a rural tertiary centre in South-South Nigeria: experience from a new rheumatology clinic Emorinken, Airenakho Dic-Ijiewere, Mercy Ofunami Erameh, Cyril Oshomah Ugheoke, Asuwemhe Johnson Agbadaola, Oluwaseun Remi Agbebaku, Folasade Ojuolape Reumatologia Original Paper OBJECTIVES: Systemic lupus erythematosus (SLE) is an autoimmune disorder with a poorly understood aetiology. It predominantly affects females and has a variety of clinical manifestations. In Nigeria, there are limited data on the prevalence and burden of the disease. This study aimed to determine the clinical and laboratory profiles of SLE patients seen in a new rheumatology clinic in South-South Nigeria. MATERIAL AND METHODS: This was a retrospective cross-sectional study conducted over five years (January 2016 to December 2020). The case files of patients that satisfied the diagnosis of SLE were reviewed. The diagnosis was based on the 1997 update of the American College of Rheumatology revised criteria for the classification of SLE. The sociodemographic, clinical, and immunological data were extracted from case records. Data analysis was carried out using IBM SPSS statistics(®) 2012 version 21.0. RESULTS: Fifty-two patients were diagnosed with SLE, giving a frequency of 4.7%. Forty-seven (90.4%) of the study participants were females, with a female-to-male ratio of 9.4 : 1. The mean age of the study group was 28.42 years. The mean duration of disease before diagnosis was 4.04 months with a range of 1–15 months. The patients had various organ system manifestations, with polyarthritis being the commonest (86.5%). Others included mucocutaneous (78.8%), haematological (69.2%), serositis (40.4%), renal (38.5%), and neurological (25%) manifestations. Antinuclear antibody (ANA) assay and anti-double-stranded DNA were positive in 100% and 69.2% of patients, respectively. All patients were placed on steroids, and 96.2% had hydroxychloroquine. None of the patients were on biologic disease-modifying antirheumatic drugs. CONCLUSIONS: This study’s results are consistent with data from other African countries. To fully understand the burden and epidemiology of SLE in Nigeria, a larger prospective study is needed. Narodowy Instytut Geriatrii, Reumatologii i Rehabilitacji w Warszawie 2021-12-09 2021 /pmc/articles/PMC8768036/ /pubmed/35079185 http://dx.doi.org/10.5114/reum.2021.111714 Text en Copyright: © 2021 Narodowy Instytut Geriatrii, Reumatologii i Rehabilitacji w Warszawie https://creativecommons.org/licenses/by-nc-sa/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0) License, allowing third parties to copy and redistribute the material in any medium or format and to remix, transform, and build upon the material, provided the original work is properly cited and states its license. |
spellingShingle | Original Paper Emorinken, Airenakho Dic-Ijiewere, Mercy Ofunami Erameh, Cyril Oshomah Ugheoke, Asuwemhe Johnson Agbadaola, Oluwaseun Remi Agbebaku, Folasade Ojuolape Clinical and laboratory profile of systemic lupus erythematosus patients at a rural tertiary centre in South-South Nigeria: experience from a new rheumatology clinic |
title | Clinical and laboratory profile of systemic lupus erythematosus patients at a rural tertiary centre in South-South Nigeria: experience from a new rheumatology clinic |
title_full | Clinical and laboratory profile of systemic lupus erythematosus patients at a rural tertiary centre in South-South Nigeria: experience from a new rheumatology clinic |
title_fullStr | Clinical and laboratory profile of systemic lupus erythematosus patients at a rural tertiary centre in South-South Nigeria: experience from a new rheumatology clinic |
title_full_unstemmed | Clinical and laboratory profile of systemic lupus erythematosus patients at a rural tertiary centre in South-South Nigeria: experience from a new rheumatology clinic |
title_short | Clinical and laboratory profile of systemic lupus erythematosus patients at a rural tertiary centre in South-South Nigeria: experience from a new rheumatology clinic |
title_sort | clinical and laboratory profile of systemic lupus erythematosus patients at a rural tertiary centre in south-south nigeria: experience from a new rheumatology clinic |
topic | Original Paper |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8768036/ https://www.ncbi.nlm.nih.gov/pubmed/35079185 http://dx.doi.org/10.5114/reum.2021.111714 |
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