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Radiation Necrosis with Proton Therapy in a Patient with Aarskog-Scott Syndrome and Medulloblastoma
PURPOSE: Medulloblastoma is known to be associated with multiple cancer-predisposition syndromes. In this article, we explore a possible association among a patient's Aarskog-Scott syndrome, development of medulloblastoma, and subsequent brainstem radiation necrosis. CASE PRESENTATION: A 5-year...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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The Particle Therapy Co-operative Group
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8768897/ https://www.ncbi.nlm.nih.gov/pubmed/35127977 http://dx.doi.org/10.14338/IJPT-21-00013.1 |
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author | Puthenpura, Vidya DeNunzio, Nicholas J. Zeng, Xue Giantsoudi, Drosoula Aboian, Mariam Ebb, David Kahle, Kristopher T. Yock, Torunn I. Marks, Asher M. |
author_facet | Puthenpura, Vidya DeNunzio, Nicholas J. Zeng, Xue Giantsoudi, Drosoula Aboian, Mariam Ebb, David Kahle, Kristopher T. Yock, Torunn I. Marks, Asher M. |
author_sort | Puthenpura, Vidya |
collection | PubMed |
description | PURPOSE: Medulloblastoma is known to be associated with multiple cancer-predisposition syndromes. In this article, we explore a possible association among a patient's Aarskog-Scott syndrome, development of medulloblastoma, and subsequent brainstem radiation necrosis. CASE PRESENTATION: A 5-year-old male with Aarskog-Scott syndrome initially presented to his pediatrician with morning emesis, gait instability, and truncal weakness. He was ultimately found to have a posterior fossa tumor with pathology consistent with group 3 medulloblastoma. After receiving a gross total resection and standard proton beam radiation therapy with concurrent vincristine, he was noted to develop brainstem radiation necrosis, for which he underwent therapy with high-dose dexamethasone, bevacizumab, and hyperbaric oxygen therapy with radiographic improvement and clinical stabilization. CONCLUSION: Based on several possible pathologic correlates in the FDG1 pathway, there exists a potential association between this patient's Aarskog-Scott syndrome and medulloblastoma, which needs to be investigated further. In patients with underlying, rare genetic syndromes, further caution should be taken when evaluating chemotherapy and radiation dosimetry planning. |
format | Online Article Text |
id | pubmed-8768897 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | The Particle Therapy Co-operative Group |
record_format | MEDLINE/PubMed |
spelling | pubmed-87688972022-02-03 Radiation Necrosis with Proton Therapy in a Patient with Aarskog-Scott Syndrome and Medulloblastoma Puthenpura, Vidya DeNunzio, Nicholas J. Zeng, Xue Giantsoudi, Drosoula Aboian, Mariam Ebb, David Kahle, Kristopher T. Yock, Torunn I. Marks, Asher M. Int J Part Ther Case Reports PURPOSE: Medulloblastoma is known to be associated with multiple cancer-predisposition syndromes. In this article, we explore a possible association among a patient's Aarskog-Scott syndrome, development of medulloblastoma, and subsequent brainstem radiation necrosis. CASE PRESENTATION: A 5-year-old male with Aarskog-Scott syndrome initially presented to his pediatrician with morning emesis, gait instability, and truncal weakness. He was ultimately found to have a posterior fossa tumor with pathology consistent with group 3 medulloblastoma. After receiving a gross total resection and standard proton beam radiation therapy with concurrent vincristine, he was noted to develop brainstem radiation necrosis, for which he underwent therapy with high-dose dexamethasone, bevacizumab, and hyperbaric oxygen therapy with radiographic improvement and clinical stabilization. CONCLUSION: Based on several possible pathologic correlates in the FDG1 pathway, there exists a potential association between this patient's Aarskog-Scott syndrome and medulloblastoma, which needs to be investigated further. In patients with underlying, rare genetic syndromes, further caution should be taken when evaluating chemotherapy and radiation dosimetry planning. The Particle Therapy Co-operative Group 2021-07-29 /pmc/articles/PMC8768897/ /pubmed/35127977 http://dx.doi.org/10.14338/IJPT-21-00013.1 Text en ©Copyright 2021 The Author(s) https://creativecommons.org/licenses/by/3.0/This is an Open Access article distributed in accordance with Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0/ (https://creativecommons.org/licenses/by/3.0/) ). |
spellingShingle | Case Reports Puthenpura, Vidya DeNunzio, Nicholas J. Zeng, Xue Giantsoudi, Drosoula Aboian, Mariam Ebb, David Kahle, Kristopher T. Yock, Torunn I. Marks, Asher M. Radiation Necrosis with Proton Therapy in a Patient with Aarskog-Scott Syndrome and Medulloblastoma |
title | Radiation Necrosis with Proton Therapy in a Patient with Aarskog-Scott Syndrome and Medulloblastoma |
title_full | Radiation Necrosis with Proton Therapy in a Patient with Aarskog-Scott Syndrome and Medulloblastoma |
title_fullStr | Radiation Necrosis with Proton Therapy in a Patient with Aarskog-Scott Syndrome and Medulloblastoma |
title_full_unstemmed | Radiation Necrosis with Proton Therapy in a Patient with Aarskog-Scott Syndrome and Medulloblastoma |
title_short | Radiation Necrosis with Proton Therapy in a Patient with Aarskog-Scott Syndrome and Medulloblastoma |
title_sort | radiation necrosis with proton therapy in a patient with aarskog-scott syndrome and medulloblastoma |
topic | Case Reports |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8768897/ https://www.ncbi.nlm.nih.gov/pubmed/35127977 http://dx.doi.org/10.14338/IJPT-21-00013.1 |
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