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Comparative Effectiveness of Proton Therapy versus Photon Radiotherapy in Adolescents and Young Adults for Classical Hodgkin Lymphoma

PURPOSE: Early stage (stages I-II) classical Hodgkin lymphoma (cHL) is a highly curable disease typically diagnosed in adolescents and young adults (AYAs). Proton therapy can also reduce the late toxicity burden in this population, but data on its comparative efficacy with photon radiotherapy in thi...

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Autores principales: Bates, James E., Terezakis, Stephanie, Morris, Christopher G., Rao, Avani D., Sehgal, Shuchi, Kumar, Rahul, Mailhot Vega, Raymond B., Mendenhall, Nancy P., Hoppe, Bradford S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Particle Therapy Co-operative Group 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8768899/
https://www.ncbi.nlm.nih.gov/pubmed/35127972
http://dx.doi.org/10.14338/IJPT-21-00011.1
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author Bates, James E.
Terezakis, Stephanie
Morris, Christopher G.
Rao, Avani D.
Sehgal, Shuchi
Kumar, Rahul
Mailhot Vega, Raymond B.
Mendenhall, Nancy P.
Hoppe, Bradford S.
author_facet Bates, James E.
Terezakis, Stephanie
Morris, Christopher G.
Rao, Avani D.
Sehgal, Shuchi
Kumar, Rahul
Mailhot Vega, Raymond B.
Mendenhall, Nancy P.
Hoppe, Bradford S.
author_sort Bates, James E.
collection PubMed
description PURPOSE: Early stage (stages I-II) classical Hodgkin lymphoma (cHL) is a highly curable disease typically diagnosed in adolescents and young adults (AYAs). Proton therapy can also reduce the late toxicity burden in this population, but data on its comparative efficacy with photon radiotherapy in this population are sparse. We assessed outcomes in AYAs with cHL in a multi-institution retrospective review. MATERIALS AND METHODS: We identified 94 patients aged 15 to 40 years with stages I and II cHL treated with radiotherapy as part of their initial treatment between 2008 and 2017. We used Kaplan-Meier analyses and log-rank testing to evaluate survival differences between groups of patients. RESULTS: A total of 91 patients were included in the analysis. The 2-year progression-free survival (PFS) rate was 89%. Of the 12 patients who experienced progression after radiotherapy, 4 occurred out-of-field, 2 occurred in-field, and 6 experienced both in- and out-of-field progression. There was no significant difference in 2-year PFS among AYA patients by radiotherapy dose received (≥ 30 Gy, 91%; < 30 Gy, 86%; P = .82). Likewise, there was no difference in 2-year PFS among patients who received either proton or photon radiotherapy (proton, 94%; photon, 83%; P = .07). CONCLUSION: Our cohort of AYA patients had comparable outcomes regardless of radiotherapy dose or modality used. For patients with significant risk of radiation-induced late effects, proton therapy is a reasonable treatment modality.
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spelling pubmed-87688992022-02-03 Comparative Effectiveness of Proton Therapy versus Photon Radiotherapy in Adolescents and Young Adults for Classical Hodgkin Lymphoma Bates, James E. Terezakis, Stephanie Morris, Christopher G. Rao, Avani D. Sehgal, Shuchi Kumar, Rahul Mailhot Vega, Raymond B. Mendenhall, Nancy P. Hoppe, Bradford S. Int J Part Ther Original Articles PURPOSE: Early stage (stages I-II) classical Hodgkin lymphoma (cHL) is a highly curable disease typically diagnosed in adolescents and young adults (AYAs). Proton therapy can also reduce the late toxicity burden in this population, but data on its comparative efficacy with photon radiotherapy in this population are sparse. We assessed outcomes in AYAs with cHL in a multi-institution retrospective review. MATERIALS AND METHODS: We identified 94 patients aged 15 to 40 years with stages I and II cHL treated with radiotherapy as part of their initial treatment between 2008 and 2017. We used Kaplan-Meier analyses and log-rank testing to evaluate survival differences between groups of patients. RESULTS: A total of 91 patients were included in the analysis. The 2-year progression-free survival (PFS) rate was 89%. Of the 12 patients who experienced progression after radiotherapy, 4 occurred out-of-field, 2 occurred in-field, and 6 experienced both in- and out-of-field progression. There was no significant difference in 2-year PFS among AYA patients by radiotherapy dose received (≥ 30 Gy, 91%; < 30 Gy, 86%; P = .82). Likewise, there was no difference in 2-year PFS among patients who received either proton or photon radiotherapy (proton, 94%; photon, 83%; P = .07). CONCLUSION: Our cohort of AYA patients had comparable outcomes regardless of radiotherapy dose or modality used. For patients with significant risk of radiation-induced late effects, proton therapy is a reasonable treatment modality. The Particle Therapy Co-operative Group 2021-07-08 /pmc/articles/PMC8768899/ /pubmed/35127972 http://dx.doi.org/10.14338/IJPT-21-00011.1 Text en ©Copyright 2021 The Author(s) https://creativecommons.org/licenses/by/3.0/This is an Open Access article distributed in accordance with Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0/ (https://creativecommons.org/licenses/by/3.0/) ).
spellingShingle Original Articles
Bates, James E.
Terezakis, Stephanie
Morris, Christopher G.
Rao, Avani D.
Sehgal, Shuchi
Kumar, Rahul
Mailhot Vega, Raymond B.
Mendenhall, Nancy P.
Hoppe, Bradford S.
Comparative Effectiveness of Proton Therapy versus Photon Radiotherapy in Adolescents and Young Adults for Classical Hodgkin Lymphoma
title Comparative Effectiveness of Proton Therapy versus Photon Radiotherapy in Adolescents and Young Adults for Classical Hodgkin Lymphoma
title_full Comparative Effectiveness of Proton Therapy versus Photon Radiotherapy in Adolescents and Young Adults for Classical Hodgkin Lymphoma
title_fullStr Comparative Effectiveness of Proton Therapy versus Photon Radiotherapy in Adolescents and Young Adults for Classical Hodgkin Lymphoma
title_full_unstemmed Comparative Effectiveness of Proton Therapy versus Photon Radiotherapy in Adolescents and Young Adults for Classical Hodgkin Lymphoma
title_short Comparative Effectiveness of Proton Therapy versus Photon Radiotherapy in Adolescents and Young Adults for Classical Hodgkin Lymphoma
title_sort comparative effectiveness of proton therapy versus photon radiotherapy in adolescents and young adults for classical hodgkin lymphoma
topic Original Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8768899/
https://www.ncbi.nlm.nih.gov/pubmed/35127972
http://dx.doi.org/10.14338/IJPT-21-00011.1
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