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High-Throughput Screening and Quantum Mechanics for Identifying Potent Inhibitors Against Mac1 Domain of SARS-CoV-2 Nsp3

SARS-CoV-2 encodes the Mac1 domain within the large nonstructural protein 3 (Nsp3), which has an ADP-ribosylhydrolase activity conserved in other coronaviruses. The enzymatic activity of Mac1 makes it an essential virulence factor for the pathogenicity of coronavirus (CoV). They have a regulatory ro...

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Detalles Bibliográficos
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	IEEE 2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8769010/ https://www.ncbi.nlm.nih.gov/pubmed/33306471 http://dx.doi.org/10.1109/TCBB.2020.3037136

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