Case Report: An Unusual Case of Ectopic ACTH Syndrome Caused by Mediastinal Paraganglioma

Ectopic adrenocorticotrophic hormone (ACTH) syndrome is not common, which is more unusual when caused by paraganglioma. We herein present a 40-year-old Chinese male who was diagnosed with ACTH-dependent Cushing’s syndrome. However, the localization of the ACTH source was troublesome due to the incon...

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Detalles Bibliográficos
Autores principales: Li, Bo, Yan, Zhe, Huang, Hui
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Endocrinology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8769203/
https://www.ncbi.nlm.nih.gov/pubmed/35069444
http://dx.doi.org/10.3389/fendo.2021.790975
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author Li, Bo
Yan, Zhe
Huang, Hui
author_facet Li, Bo
Yan, Zhe
Huang, Hui
author_sort Li, Bo
collection PubMed
description Ectopic adrenocorticotrophic hormone (ACTH) syndrome is not common, which is more unusual when caused by paraganglioma. We herein present a 40-year-old Chinese male who was diagnosed with ACTH-dependent Cushing’s syndrome. However, the localization of the ACTH source was troublesome due to the inconsistent results of the high-dose dexamethasone suppression test and the desmopressin stimulation test. Bilateral inferior petrosal sinus sampling was performed, and ectopic ACTH syndrome was diagnosed. After (68)Ga-DOTATATE-PET/CT and (18)F-FDG-PET/CT were performed, it was localized in the anterior mediastinum. Post-operation histopathology demonstrated an ACTH-secreting mediastinal paraganglioma. The patient obtained complete clinical remission after a mediastinal tumorectomy.
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spelling pubmed-87692032022-01-20 Case Report: An Unusual Case of Ectopic ACTH Syndrome Caused by Mediastinal Paraganglioma Li, Bo Yan, Zhe Huang, Hui Front Endocrinol (Lausanne) Endocrinology Ectopic adrenocorticotrophic hormone (ACTH) syndrome is not common, which is more unusual when caused by paraganglioma. We herein present a 40-year-old Chinese male who was diagnosed with ACTH-dependent Cushing’s syndrome. However, the localization of the ACTH source was troublesome due to the inconsistent results of the high-dose dexamethasone suppression test and the desmopressin stimulation test. Bilateral inferior petrosal sinus sampling was performed, and ectopic ACTH syndrome was diagnosed. After (68)Ga-DOTATATE-PET/CT and (18)F-FDG-PET/CT were performed, it was localized in the anterior mediastinum. Post-operation histopathology demonstrated an ACTH-secreting mediastinal paraganglioma. The patient obtained complete clinical remission after a mediastinal tumorectomy. Frontiers Media S.A. 2022-01-05 /pmc/articles/PMC8769203/ /pubmed/35069444 http://dx.doi.org/10.3389/fendo.2021.790975 Text en Copyright © 2022 Li, Yan and Huang https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Endocrinology
Li, Bo
Yan, Zhe
Huang, Hui
Case Report: An Unusual Case of Ectopic ACTH Syndrome Caused by Mediastinal Paraganglioma
title Case Report: An Unusual Case of Ectopic ACTH Syndrome Caused by Mediastinal Paraganglioma
title_full Case Report: An Unusual Case of Ectopic ACTH Syndrome Caused by Mediastinal Paraganglioma
title_fullStr Case Report: An Unusual Case of Ectopic ACTH Syndrome Caused by Mediastinal Paraganglioma
title_full_unstemmed Case Report: An Unusual Case of Ectopic ACTH Syndrome Caused by Mediastinal Paraganglioma
title_short Case Report: An Unusual Case of Ectopic ACTH Syndrome Caused by Mediastinal Paraganglioma
title_sort case report: an unusual case of ectopic acth syndrome caused by mediastinal paraganglioma
topic Endocrinology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8769203/
https://www.ncbi.nlm.nih.gov/pubmed/35069444
http://dx.doi.org/10.3389/fendo.2021.790975
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