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Prebiotic Supplementation During Gestation Induces a Tolerogenic Environment and a Protective Microbiota in Offspring Mitigating Food Allergy

Food allergy is associated with alterations in the gut microbiota, epithelial barrier, and immune tolerance. These dysfunctions are observed within the first months of life, indicating that early intervention is crucial for disease prevention. Preventive nutritional strategies with prebiotics are an...

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Autores principales: Selle, Amandine, Brosseau, Carole, Dijk, Wieneke, Duval, Angéline, Bouchaud, Grégory, Rousseaux, Anais, Bruneau, Aurélia, Cherbuy, Claire, Mariadassou, Mahendra, Cariou, Véronique, Barbarot, Sebastien, Bodinier, Marie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8769244/
https://www.ncbi.nlm.nih.gov/pubmed/35069524
http://dx.doi.org/10.3389/fimmu.2021.745535
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author Selle, Amandine
Brosseau, Carole
Dijk, Wieneke
Duval, Angéline
Bouchaud, Grégory
Rousseaux, Anais
Bruneau, Aurélia
Cherbuy, Claire
Mariadassou, Mahendra
Cariou, Véronique
Barbarot, Sebastien
Bodinier, Marie
author_facet Selle, Amandine
Brosseau, Carole
Dijk, Wieneke
Duval, Angéline
Bouchaud, Grégory
Rousseaux, Anais
Bruneau, Aurélia
Cherbuy, Claire
Mariadassou, Mahendra
Cariou, Véronique
Barbarot, Sebastien
Bodinier, Marie
author_sort Selle, Amandine
collection PubMed
description Food allergy is associated with alterations in the gut microbiota, epithelial barrier, and immune tolerance. These dysfunctions are observed within the first months of life, indicating that early intervention is crucial for disease prevention. Preventive nutritional strategies with prebiotics are an attractive option, as prebiotics such as galacto-oligosaccharides and inulin can promote tolerance, epithelial barrier reinforcement, and gut microbiota modulation. Nonetheless, the ideal period for intervention remains unknown. Here, we investigated whether galacto-oligosaccharide/inulin supplementation during gestation could protect offspring from wheat allergy development in BALB/cJRj mice. We demonstrated that gestational prebiotic supplementation promoted the presence of beneficial strains in the fecal microbiota of dams during gestation and partially during mid-lactation. This specific microbiota was transferred to their offspring and maintained to adulthood. The presence of B and T regulatory immune cell subsets was also increased in the lymph nodes of offspring born from supplemented mothers, suggestive of a more tolerogenic immune environment. Indeed, antenatal prebiotic supplementation reduced the development of wheat allergy symptoms in offspring. Our study thus demonstrates that prebiotic supplementation during pregnancy induces, in the offspring, a tolerogenic environment and a microbial imprint that mitigates food allergy development.
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spelling pubmed-87692442022-01-20 Prebiotic Supplementation During Gestation Induces a Tolerogenic Environment and a Protective Microbiota in Offspring Mitigating Food Allergy Selle, Amandine Brosseau, Carole Dijk, Wieneke Duval, Angéline Bouchaud, Grégory Rousseaux, Anais Bruneau, Aurélia Cherbuy, Claire Mariadassou, Mahendra Cariou, Véronique Barbarot, Sebastien Bodinier, Marie Front Immunol Immunology Food allergy is associated with alterations in the gut microbiota, epithelial barrier, and immune tolerance. These dysfunctions are observed within the first months of life, indicating that early intervention is crucial for disease prevention. Preventive nutritional strategies with prebiotics are an attractive option, as prebiotics such as galacto-oligosaccharides and inulin can promote tolerance, epithelial barrier reinforcement, and gut microbiota modulation. Nonetheless, the ideal period for intervention remains unknown. Here, we investigated whether galacto-oligosaccharide/inulin supplementation during gestation could protect offspring from wheat allergy development in BALB/cJRj mice. We demonstrated that gestational prebiotic supplementation promoted the presence of beneficial strains in the fecal microbiota of dams during gestation and partially during mid-lactation. This specific microbiota was transferred to their offspring and maintained to adulthood. The presence of B and T regulatory immune cell subsets was also increased in the lymph nodes of offspring born from supplemented mothers, suggestive of a more tolerogenic immune environment. Indeed, antenatal prebiotic supplementation reduced the development of wheat allergy symptoms in offspring. Our study thus demonstrates that prebiotic supplementation during pregnancy induces, in the offspring, a tolerogenic environment and a microbial imprint that mitigates food allergy development. Frontiers Media S.A. 2022-01-05 /pmc/articles/PMC8769244/ /pubmed/35069524 http://dx.doi.org/10.3389/fimmu.2021.745535 Text en Copyright © 2022 Selle, Brosseau, Dijk, Duval, Bouchaud, Rousseaux, Bruneau, Cherbuy, Mariadassou, Cariou, Barbarot and Bodinier https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Immunology
Selle, Amandine
Brosseau, Carole
Dijk, Wieneke
Duval, Angéline
Bouchaud, Grégory
Rousseaux, Anais
Bruneau, Aurélia
Cherbuy, Claire
Mariadassou, Mahendra
Cariou, Véronique
Barbarot, Sebastien
Bodinier, Marie
Prebiotic Supplementation During Gestation Induces a Tolerogenic Environment and a Protective Microbiota in Offspring Mitigating Food Allergy
title Prebiotic Supplementation During Gestation Induces a Tolerogenic Environment and a Protective Microbiota in Offspring Mitigating Food Allergy
title_full Prebiotic Supplementation During Gestation Induces a Tolerogenic Environment and a Protective Microbiota in Offspring Mitigating Food Allergy
title_fullStr Prebiotic Supplementation During Gestation Induces a Tolerogenic Environment and a Protective Microbiota in Offspring Mitigating Food Allergy
title_full_unstemmed Prebiotic Supplementation During Gestation Induces a Tolerogenic Environment and a Protective Microbiota in Offspring Mitigating Food Allergy
title_short Prebiotic Supplementation During Gestation Induces a Tolerogenic Environment and a Protective Microbiota in Offspring Mitigating Food Allergy
title_sort prebiotic supplementation during gestation induces a tolerogenic environment and a protective microbiota in offspring mitigating food allergy
topic Immunology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8769244/
https://www.ncbi.nlm.nih.gov/pubmed/35069524
http://dx.doi.org/10.3389/fimmu.2021.745535
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