Rapid and sensitive point-of-care detection of Leptospira by RPA-CRISPR/Cas12a targeting lipL32

BACKGROUND: One of the key barriers preventing rapid diagnosis of leptospirosis is the lack of available sensitive point-of-care testing. This study aimed to develop and validate a clustered regularly-interspaced short palindromic repeat (CRISPR)/CRISPR-associated protein 12a (CRISPR/Cas12a) platfor...

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Detalles Bibliográficos
Autores principales: Jirawannaporn, Sirawit, Limothai, Umaporn, Tachaboon, Sasipha, Dinhuzen, Janejira, Kiatamornrak, Patcharakorn, Chaisuriyong, Watchadaporn, Bhumitrakul, Jom, Mayuramart, Oraphan, Payungporn, Sunchai, Srisawat, Nattachai
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8769300/
https://www.ncbi.nlm.nih.gov/pubmed/34990457
http://dx.doi.org/10.1371/journal.pntd.0010112

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