Mutational analysis of Aedes aegypti Dicer 2 provides insights into the biogenesis of antiviral exogenous small interfering RNAs

The exogenous small interfering RNA (exo-siRNA) pathway is a key antiviral mechanism in the Aedes aegypti mosquito, a widely distributed vector of human-pathogenic arboviruses. This pathway is induced by virus-derived double-stranded RNAs (dsRNA) that are cleaved by the ribonuclease Dicer 2 (Dcr2) i...

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Detalles Bibliográficos
Autores principales: Gestuveo, Rommel J., Parry, Rhys, Dickson, Laura B., Lequime, Sebastian, Sreenu, Vattipally B., Arnold, Matthew J., Khromykh, Alexander A., Schnettler, Esther, Lambrechts, Louis, Varjak, Margus, Kohl, Alain
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8769306/
https://www.ncbi.nlm.nih.gov/pubmed/34990484
http://dx.doi.org/10.1371/journal.ppat.1010202

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