Cargando…

Short-term, medium-term, and long-term risks of nonvariceal upper gastrointestinal bleeding after dengue virus infection

Dengue patients have an increased risk of acute gastrointestinal (GI) bleeding. However, whether dengue virus (DENV) infection can cause an increased long-term risk of GI bleeding remains unknown, especially among elderly individuals who commonly take antithrombotic drugs. A retrospective population...

Descripción completa

Detalles Bibliográficos
Autores principales: Chien, Yu-Wen, Chuang, Hui-Ning, Wang, Yu-Ping, Perng, Guey Chuen, Chi, Chia-Yu, Shih, Hsin-I
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8769317/
https://www.ncbi.nlm.nih.gov/pubmed/35045094
http://dx.doi.org/10.1371/journal.pntd.0010039
_version_ 1784635105822638080
author Chien, Yu-Wen
Chuang, Hui-Ning
Wang, Yu-Ping
Perng, Guey Chuen
Chi, Chia-Yu
Shih, Hsin-I
author_facet Chien, Yu-Wen
Chuang, Hui-Ning
Wang, Yu-Ping
Perng, Guey Chuen
Chi, Chia-Yu
Shih, Hsin-I
author_sort Chien, Yu-Wen
collection PubMed
description Dengue patients have an increased risk of acute gastrointestinal (GI) bleeding. However, whether dengue virus (DENV) infection can cause an increased long-term risk of GI bleeding remains unknown, especially among elderly individuals who commonly take antithrombotic drugs. A retrospective population-based cohort study was conducted by analyzing the National Health Insurance Research Databases. Laboratory-confirmed dengue patients from 2002 to 2012 and four matched nondengue controls were identified. Multivariate Cox proportional hazard regression was used to evaluate the acute (<30 days), medium-term (31–365 days), and long-term (>365 days) risks of nonvariceal upper GI bleeding after DENV infection. Stratified analyses by age group (≤50, 51–64, ≥65 years old) were also performed. In total, 13267 confirmed dengue patients and 53068 nondengue matched controls were included. After adjusting for sex, age, area of residence, comorbidities, and medications, dengue patients had a significantly increased risk of nonvariceal upper GI bleeding within 30 days of disease onset (adjusted HR 55.40; 95% CI: 32.17–95.42). However, DENV infection was not associated with increased medium-term and long-term risks of upper GI bleeding overall or in each age group. Even dengue patients who developed acute GI bleeding did not have increased medium-term (adjusted HR; 0.55, 95% CI 0.05–6.18) and long-term risks of upper GI bleeding (adjusted HR; 1.78, 95% CI 0.89–3.55). DENV infection was associated with a significantly increased risk of nonvariceal upper GI bleeding within 30 days but not thereafter. Recovered dengue patients with acute GI bleeding can resume antithrombotic treatments to minimize the risk of thrombosis.
format Online
Article
Text
id pubmed-8769317
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher Public Library of Science
record_format MEDLINE/PubMed
spelling pubmed-87693172022-01-20 Short-term, medium-term, and long-term risks of nonvariceal upper gastrointestinal bleeding after dengue virus infection Chien, Yu-Wen Chuang, Hui-Ning Wang, Yu-Ping Perng, Guey Chuen Chi, Chia-Yu Shih, Hsin-I PLoS Negl Trop Dis Research Article Dengue patients have an increased risk of acute gastrointestinal (GI) bleeding. However, whether dengue virus (DENV) infection can cause an increased long-term risk of GI bleeding remains unknown, especially among elderly individuals who commonly take antithrombotic drugs. A retrospective population-based cohort study was conducted by analyzing the National Health Insurance Research Databases. Laboratory-confirmed dengue patients from 2002 to 2012 and four matched nondengue controls were identified. Multivariate Cox proportional hazard regression was used to evaluate the acute (<30 days), medium-term (31–365 days), and long-term (>365 days) risks of nonvariceal upper GI bleeding after DENV infection. Stratified analyses by age group (≤50, 51–64, ≥65 years old) were also performed. In total, 13267 confirmed dengue patients and 53068 nondengue matched controls were included. After adjusting for sex, age, area of residence, comorbidities, and medications, dengue patients had a significantly increased risk of nonvariceal upper GI bleeding within 30 days of disease onset (adjusted HR 55.40; 95% CI: 32.17–95.42). However, DENV infection was not associated with increased medium-term and long-term risks of upper GI bleeding overall or in each age group. Even dengue patients who developed acute GI bleeding did not have increased medium-term (adjusted HR; 0.55, 95% CI 0.05–6.18) and long-term risks of upper GI bleeding (adjusted HR; 1.78, 95% CI 0.89–3.55). DENV infection was associated with a significantly increased risk of nonvariceal upper GI bleeding within 30 days but not thereafter. Recovered dengue patients with acute GI bleeding can resume antithrombotic treatments to minimize the risk of thrombosis. Public Library of Science 2022-01-19 /pmc/articles/PMC8769317/ /pubmed/35045094 http://dx.doi.org/10.1371/journal.pntd.0010039 Text en © 2022 Chien et al https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Article
Chien, Yu-Wen
Chuang, Hui-Ning
Wang, Yu-Ping
Perng, Guey Chuen
Chi, Chia-Yu
Shih, Hsin-I
Short-term, medium-term, and long-term risks of nonvariceal upper gastrointestinal bleeding after dengue virus infection
title Short-term, medium-term, and long-term risks of nonvariceal upper gastrointestinal bleeding after dengue virus infection
title_full Short-term, medium-term, and long-term risks of nonvariceal upper gastrointestinal bleeding after dengue virus infection
title_fullStr Short-term, medium-term, and long-term risks of nonvariceal upper gastrointestinal bleeding after dengue virus infection
title_full_unstemmed Short-term, medium-term, and long-term risks of nonvariceal upper gastrointestinal bleeding after dengue virus infection
title_short Short-term, medium-term, and long-term risks of nonvariceal upper gastrointestinal bleeding after dengue virus infection
title_sort short-term, medium-term, and long-term risks of nonvariceal upper gastrointestinal bleeding after dengue virus infection
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8769317/
https://www.ncbi.nlm.nih.gov/pubmed/35045094
http://dx.doi.org/10.1371/journal.pntd.0010039
work_keys_str_mv AT chienyuwen shorttermmediumtermandlongtermrisksofnonvaricealuppergastrointestinalbleedingafterdenguevirusinfection
AT chuanghuining shorttermmediumtermandlongtermrisksofnonvaricealuppergastrointestinalbleedingafterdenguevirusinfection
AT wangyuping shorttermmediumtermandlongtermrisksofnonvaricealuppergastrointestinalbleedingafterdenguevirusinfection
AT pernggueychuen shorttermmediumtermandlongtermrisksofnonvaricealuppergastrointestinalbleedingafterdenguevirusinfection
AT chichiayu shorttermmediumtermandlongtermrisksofnonvaricealuppergastrointestinalbleedingafterdenguevirusinfection
AT shihhsini shorttermmediumtermandlongtermrisksofnonvaricealuppergastrointestinalbleedingafterdenguevirusinfection