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A Novel Nonsense INS Mutation Causes Inefficient Preproinsulin Translocation Into the Endoplasmic Reticulum

Preproinsulin (PPI) translocation across the membrane of the endoplasmic reticulum (ER) is the first and critical step of insulin biosynthesis. Inefficient PPI translocation caused by signal peptide (SP) mutations can lead to β-cell failure and diabetes. However, the effect of proinsulin domain on t...

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Detalles Bibliográficos
Autores principales:	Yang, Ying, Shu, Hua, Hu, Jingxin, Li, Lei, Wang, Jianyu, Chen, Tingting, Zhen, Jinyang, Sun, Jinhong, Feng, Wenli, Xiong, Yi, Huang, Yumeng, Li, Xin, Zhang, Kai, Fan, Zhenqian, Guo, Hui, Liu, Ming
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2022
Materias:	Endocrinology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8769375/ https://www.ncbi.nlm.nih.gov/pubmed/35069438 http://dx.doi.org/10.3389/fendo.2021.774634

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