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Survival Benefit of Supratotal Resection in a Long-term Survivor of IDH-wildtype Glioblastoma: A Case Report and Literature Review
Glioblastoma multiforme (GBM) is an aggressive cancer type, with fewer than 3–5% of patients surviving for more than 3 years. We describe a 48-year-old right-handed man who presented with generalized seizure attacks. Magnetic resonance imaging (MRI) revealed a heterogeneous gadolinium-enhancing lesi...
Autores principales: | , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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The Japan Neurosurgical Society
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8769439/ https://www.ncbi.nlm.nih.gov/pubmed/35079543 http://dx.doi.org/10.2176/nmccrj.cr.2021-0120 |
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author | YAMAGUCHI, Junya MOTOMURA, Kazuya OHKA, Fumiharu AOKI, Kosuke TANAHASHI, Kuniaki HIRANO, Masaki CHALISE, Lushun NISHIKAWA, Tomohide SHIMIZU, Hiroyuki NATSUME, Atsushi WAKABAYASHI, Toshihiko SAITO, Ryuta |
author_facet | YAMAGUCHI, Junya MOTOMURA, Kazuya OHKA, Fumiharu AOKI, Kosuke TANAHASHI, Kuniaki HIRANO, Masaki CHALISE, Lushun NISHIKAWA, Tomohide SHIMIZU, Hiroyuki NATSUME, Atsushi WAKABAYASHI, Toshihiko SAITO, Ryuta |
author_sort | YAMAGUCHI, Junya |
collection | PubMed |
description | Glioblastoma multiforme (GBM) is an aggressive cancer type, with fewer than 3–5% of patients surviving for more than 3 years. We describe a 48-year-old right-handed man who presented with generalized seizure attacks. Magnetic resonance imaging (MRI) revealed a heterogeneous gadolinium-enhancing lesion in the left inferior parietal lobule. The patient underwent awake surgery, and tumor resection included abnormalities on T2-weighted MRI, with subcortical mapping used to identify the deep functional boundaries. After supratotal resection, the tumor was diagnosed as GBM without isocitrate dehydrogenase (IDH) 1 and 2 mutations. At a follow-up evaluation, 9 years and 2 months after the surgery, the patient appeared healthy, and no relapse or recurrence was observed. We present the case of a long-term survivor of IDH-wildtype GBM. This case suggests that supratotal resection with intraoperative awake brain mapping can improve survival without impairing the patient’s neurological functions. |
format | Online Article Text |
id | pubmed-8769439 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | The Japan Neurosurgical Society |
record_format | MEDLINE/PubMed |
spelling | pubmed-87694392022-01-24 Survival Benefit of Supratotal Resection in a Long-term Survivor of IDH-wildtype Glioblastoma: A Case Report and Literature Review YAMAGUCHI, Junya MOTOMURA, Kazuya OHKA, Fumiharu AOKI, Kosuke TANAHASHI, Kuniaki HIRANO, Masaki CHALISE, Lushun NISHIKAWA, Tomohide SHIMIZU, Hiroyuki NATSUME, Atsushi WAKABAYASHI, Toshihiko SAITO, Ryuta NMC Case Rep J Case Report Glioblastoma multiforme (GBM) is an aggressive cancer type, with fewer than 3–5% of patients surviving for more than 3 years. We describe a 48-year-old right-handed man who presented with generalized seizure attacks. Magnetic resonance imaging (MRI) revealed a heterogeneous gadolinium-enhancing lesion in the left inferior parietal lobule. The patient underwent awake surgery, and tumor resection included abnormalities on T2-weighted MRI, with subcortical mapping used to identify the deep functional boundaries. After supratotal resection, the tumor was diagnosed as GBM without isocitrate dehydrogenase (IDH) 1 and 2 mutations. At a follow-up evaluation, 9 years and 2 months after the surgery, the patient appeared healthy, and no relapse or recurrence was observed. We present the case of a long-term survivor of IDH-wildtype GBM. This case suggests that supratotal resection with intraoperative awake brain mapping can improve survival without impairing the patient’s neurological functions. The Japan Neurosurgical Society 2021-11-02 /pmc/articles/PMC8769439/ /pubmed/35079543 http://dx.doi.org/10.2176/nmccrj.cr.2021-0120 Text en © 2021 The Japan Neurosurgical Society https://creativecommons.org/licenses/by-nc-nd/4.0/This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-nd/4.0/ (https://creativecommons.org/licenses/by-nc-nd/4.0/) |
spellingShingle | Case Report YAMAGUCHI, Junya MOTOMURA, Kazuya OHKA, Fumiharu AOKI, Kosuke TANAHASHI, Kuniaki HIRANO, Masaki CHALISE, Lushun NISHIKAWA, Tomohide SHIMIZU, Hiroyuki NATSUME, Atsushi WAKABAYASHI, Toshihiko SAITO, Ryuta Survival Benefit of Supratotal Resection in a Long-term Survivor of IDH-wildtype Glioblastoma: A Case Report and Literature Review |
title | Survival Benefit of Supratotal Resection in a Long-term Survivor of IDH-wildtype Glioblastoma: A Case Report and Literature Review |
title_full | Survival Benefit of Supratotal Resection in a Long-term Survivor of IDH-wildtype Glioblastoma: A Case Report and Literature Review |
title_fullStr | Survival Benefit of Supratotal Resection in a Long-term Survivor of IDH-wildtype Glioblastoma: A Case Report and Literature Review |
title_full_unstemmed | Survival Benefit of Supratotal Resection in a Long-term Survivor of IDH-wildtype Glioblastoma: A Case Report and Literature Review |
title_short | Survival Benefit of Supratotal Resection in a Long-term Survivor of IDH-wildtype Glioblastoma: A Case Report and Literature Review |
title_sort | survival benefit of supratotal resection in a long-term survivor of idh-wildtype glioblastoma: a case report and literature review |
topic | Case Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8769439/ https://www.ncbi.nlm.nih.gov/pubmed/35079543 http://dx.doi.org/10.2176/nmccrj.cr.2021-0120 |
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