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Survival Benefit of Supratotal Resection in a Long-term Survivor of IDH-wildtype Glioblastoma: A Case Report and Literature Review

Glioblastoma multiforme (GBM) is an aggressive cancer type, with fewer than 3–5% of patients surviving for more than 3 years. We describe a 48-year-old right-handed man who presented with generalized seizure attacks. Magnetic resonance imaging (MRI) revealed a heterogeneous gadolinium-enhancing lesi...

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Autores principales: YAMAGUCHI, Junya, MOTOMURA, Kazuya, OHKA, Fumiharu, AOKI, Kosuke, TANAHASHI, Kuniaki, HIRANO, Masaki, CHALISE, Lushun, NISHIKAWA, Tomohide, SHIMIZU, Hiroyuki, NATSUME, Atsushi, WAKABAYASHI, Toshihiko, SAITO, Ryuta
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Japan Neurosurgical Society 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8769439/
https://www.ncbi.nlm.nih.gov/pubmed/35079543
http://dx.doi.org/10.2176/nmccrj.cr.2021-0120
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author YAMAGUCHI, Junya
MOTOMURA, Kazuya
OHKA, Fumiharu
AOKI, Kosuke
TANAHASHI, Kuniaki
HIRANO, Masaki
CHALISE, Lushun
NISHIKAWA, Tomohide
SHIMIZU, Hiroyuki
NATSUME, Atsushi
WAKABAYASHI, Toshihiko
SAITO, Ryuta
author_facet YAMAGUCHI, Junya
MOTOMURA, Kazuya
OHKA, Fumiharu
AOKI, Kosuke
TANAHASHI, Kuniaki
HIRANO, Masaki
CHALISE, Lushun
NISHIKAWA, Tomohide
SHIMIZU, Hiroyuki
NATSUME, Atsushi
WAKABAYASHI, Toshihiko
SAITO, Ryuta
author_sort YAMAGUCHI, Junya
collection PubMed
description Glioblastoma multiforme (GBM) is an aggressive cancer type, with fewer than 3–5% of patients surviving for more than 3 years. We describe a 48-year-old right-handed man who presented with generalized seizure attacks. Magnetic resonance imaging (MRI) revealed a heterogeneous gadolinium-enhancing lesion in the left inferior parietal lobule. The patient underwent awake surgery, and tumor resection included abnormalities on T2-weighted MRI, with subcortical mapping used to identify the deep functional boundaries. After supratotal resection, the tumor was diagnosed as GBM without isocitrate dehydrogenase (IDH) 1 and 2 mutations. At a follow-up evaluation, 9 years and 2 months after the surgery, the patient appeared healthy, and no relapse or recurrence was observed. We present the case of a long-term survivor of IDH-wildtype GBM. This case suggests that supratotal resection with intraoperative awake brain mapping can improve survival without impairing the patient’s neurological functions.
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spelling pubmed-87694392022-01-24 Survival Benefit of Supratotal Resection in a Long-term Survivor of IDH-wildtype Glioblastoma: A Case Report and Literature Review YAMAGUCHI, Junya MOTOMURA, Kazuya OHKA, Fumiharu AOKI, Kosuke TANAHASHI, Kuniaki HIRANO, Masaki CHALISE, Lushun NISHIKAWA, Tomohide SHIMIZU, Hiroyuki NATSUME, Atsushi WAKABAYASHI, Toshihiko SAITO, Ryuta NMC Case Rep J Case Report Glioblastoma multiforme (GBM) is an aggressive cancer type, with fewer than 3–5% of patients surviving for more than 3 years. We describe a 48-year-old right-handed man who presented with generalized seizure attacks. Magnetic resonance imaging (MRI) revealed a heterogeneous gadolinium-enhancing lesion in the left inferior parietal lobule. The patient underwent awake surgery, and tumor resection included abnormalities on T2-weighted MRI, with subcortical mapping used to identify the deep functional boundaries. After supratotal resection, the tumor was diagnosed as GBM without isocitrate dehydrogenase (IDH) 1 and 2 mutations. At a follow-up evaluation, 9 years and 2 months after the surgery, the patient appeared healthy, and no relapse or recurrence was observed. We present the case of a long-term survivor of IDH-wildtype GBM. This case suggests that supratotal resection with intraoperative awake brain mapping can improve survival without impairing the patient’s neurological functions. The Japan Neurosurgical Society 2021-11-02 /pmc/articles/PMC8769439/ /pubmed/35079543 http://dx.doi.org/10.2176/nmccrj.cr.2021-0120 Text en © 2021 The Japan Neurosurgical Society https://creativecommons.org/licenses/by-nc-nd/4.0/This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-nd/4.0/ (https://creativecommons.org/licenses/by-nc-nd/4.0/)
spellingShingle Case Report
YAMAGUCHI, Junya
MOTOMURA, Kazuya
OHKA, Fumiharu
AOKI, Kosuke
TANAHASHI, Kuniaki
HIRANO, Masaki
CHALISE, Lushun
NISHIKAWA, Tomohide
SHIMIZU, Hiroyuki
NATSUME, Atsushi
WAKABAYASHI, Toshihiko
SAITO, Ryuta
Survival Benefit of Supratotal Resection in a Long-term Survivor of IDH-wildtype Glioblastoma: A Case Report and Literature Review
title Survival Benefit of Supratotal Resection in a Long-term Survivor of IDH-wildtype Glioblastoma: A Case Report and Literature Review
title_full Survival Benefit of Supratotal Resection in a Long-term Survivor of IDH-wildtype Glioblastoma: A Case Report and Literature Review
title_fullStr Survival Benefit of Supratotal Resection in a Long-term Survivor of IDH-wildtype Glioblastoma: A Case Report and Literature Review
title_full_unstemmed Survival Benefit of Supratotal Resection in a Long-term Survivor of IDH-wildtype Glioblastoma: A Case Report and Literature Review
title_short Survival Benefit of Supratotal Resection in a Long-term Survivor of IDH-wildtype Glioblastoma: A Case Report and Literature Review
title_sort survival benefit of supratotal resection in a long-term survivor of idh-wildtype glioblastoma: a case report and literature review
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8769439/
https://www.ncbi.nlm.nih.gov/pubmed/35079543
http://dx.doi.org/10.2176/nmccrj.cr.2021-0120
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