Targeted gene silencing in the nervous system with CRISPR-Cas13

Cas13 nucleases are a class of programmable RNA-targeting CRISPR effector proteins that are capable of silencing target gene expression in mammalian cells. Here, we demonstrate that RfxCas13d, a Cas13 ortholog with favorable characteristics to other family members, can be delivered to the mouse spin...

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Detalles Bibliográficos
Autores principales: Powell, Jackson E., Lim, Colin K. W., Krishnan, Ramya, McCallister, Tristan X., Saporito-Magriña, Christian, Zeballos, Maria A., McPheron, Garrett D., Gaj, Thomas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2022
Materias:
Biomedicine and Life Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8769545/
https://www.ncbi.nlm.nih.gov/pubmed/35044815
http://dx.doi.org/10.1126/sciadv.abk2485

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8769545/
https://www.ncbi.nlm.nih.gov/pubmed/35044815
http://dx.doi.org/10.1126/sciadv.abk2485

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